ArticleEuropean journal of immunology2016
Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα
Article in European journal of immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire.Nature immunology · 2025Article
- Thymic Dendritic Cells Revisited.Immunological reviews · 2025Review
- Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance.Immunological reviews · 2025Review
- Antigen presentation for central tolerance induction.Nature reviews. Immunology · 2025Review
- Encapsulation and immune protection for type 1 diabetes cell therapy.Advanced drug delivery reviews · 2024Review
- Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants.Scientific reports · 2022Article
- Article
- Type 2 cytokines in the thymus activate SirpαNature immunology · 2022Article
- Quantification of dendritic cell subsets in human thymus tissues of various ages.Immunity & ageing : I & A · 2021Article
- The thymus medulla and its control of αβT cell development.Seminars in immunopathology · 2021Review
- Age-Related Changes in Thymic Central Tolerance.Frontiers in immunology · 2021Review
- The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes.Frontiers in immunology · 2020Review
- Early childhood education is critical for TNature immunology · 2019Article
- Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance.Nature communications · 2019Article
- Thymus-specific serine protease, a protease that shapes the CD4 T cell repertoire.Immunogenetics · 2019Review
- Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection.Seminars in cell & developmental biology · 2018Review
- Aire controls the recirculation of murine Foxp3European journal of immunology · 2018Article
- Redefining thymus medulla specialization for central tolerance.The Journal of experimental medicine · 2017Article
- Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Dysregulation of negative selection contributes to T-cell-mediated autoimmunity, such as type 1 diabetes. The events regulating thymic negative selection, however, are ill defined. Work by our group and others suggest that negative selection is inefficient early in ontogeny and increases with age. This study examines temporal changes in negative selection and the thymic DC compartment. Peptide-induced thymocyte deletion in vivo was reduced in newborn versus 4-week-old NOD mice, despite a similar sensitivity of the respective thymocytes to apoptosis induction. The temporal increase in negative selection corresponded with an elevated capacity of thymic antigen-presenting cells to stimulate T cells, along with altered subset composition and function of resident DC. The frequency of signal regulatory protein α
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Registered trials
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