Evidence map›Paper›PMID 27501251›Full record

ArticleACS chemical neuroscience2016

Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.

Tatsuya Toma, Matthew M Logan, Frederic Menard, A Sloan Devlin, J Du Bois

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Single rat muscle NaProceedings of the National Academy of Sciences of the United States of America · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tatsuya TomaDepartment of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
Matthew M LoganDepartment of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
Frederic MenardDepartment of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
A Sloan DevlinDepartment of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
J Du BoisDepartment of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
Stanford University · US

Funding

Reaction Design for the Synthesis of Neuroactive AgentsR01NS045684 · NINDS · STANFORD UNIVERSITY · PI DU BOIS, JUSTIN · 2003 to 2011
$3.0M
NINDS NIH HHS R01 NS045684
6 · The paper itself

Abstract

A novel family of small molecule inhibitors of voltage-gated sodium channels (Na

Indexed as

AnimalsBatrachotoxinsCHO CellsCricetulusDose-Response Relationship, DrugDrug Evaluation, PreclinicalModels, MolecularMolecular StructureMuscle ProteinsMutationPatch-Clamp TechniquesRatsSodium Channel BlockersSodium ChannelsStructure-Activity RelationshipBatrachotoxinsMuscle ProteinsScn4a protein, ratSodium Channel BlockersSodium Channelsbatrachotoxinelectrophysiologyprotein mutagenesisSARSite IIsodium channel

Identifiers

PMID27501251
PMCPMC5555364
OpenAlexW2484846274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.