ArticleAnaesthesia2016
Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort.
Article in Anaesthesia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Pooled it
- Neuromonitoring depth of anesthesia and its association with postoperative delirium.Scientific reports · 2022Trial
- Cerebellar Electrical Activity as a Marker for Predicting Brain Health and Disease: A Review.Brain sciences · 2026Review
- "I'm Having the Worst Time": The Lived Experiences of Informal Caregivers for Older Adults Undergoing Major Elective Surgery.Annals of surgery · 2026Article
- Comparison of efficacy and safety of remimazolam and midazolam in elderly patients undergoing laparoscopic cholecystectomy: a retrospective study.Scientific reports · 2026Article
- Arthroscopic shoulder surgery in the beach chair position under single interscalene block does not affect patients' cognitive function.JSES international · 2026Article
- Article
- Do people with cognitive impairment benefit from cochlear implants? A scoping review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Preparing for and Not Waiting for Surgery.Current oncology (Toronto, Ont.) · 2024Review
- The Postoperative Effects of Anesthesia Exposure on Cognitive Decline in Older Adults: A Narrative Review.Current Alzheimer research · 2024Review
- Genotype- and sex-specific changes in vital parameters during isoflurane anesthesia in a mouse model of Alzheimer's disease.Frontiers in medicine · 2024Article
- Article
- The effect of opioid-sparing anesthesia regimen on short-term cognitive function after thoracoscopic surgery: a prospective cohort study.Perioperative medicine (London, England) · 2022Article
- Cognitive impairment is associated with greater preoperative symptoms, worse health-related quality of life, and reduced likelihood of recovery after cervical and lumbar spine surgery.North American Spine Society journal · 2022Article
- Gene-Specific DNA Methylation Linked to Postoperative Cognitive Dysfunction in Apolipoprotein E3 and E4 Mice.Journal of Alzheimer's disease : JAD · 2021Article
- Apolipoprotein E ε4 and cognitive function after surgery in middle-aged and elderly Danish twins.European journal of anaesthesiology · 2020Article
- Receipt of Eye Care Services among Medicare Beneficiaries with and without Dementia.Ophthalmology · 2020Article
- Anesthesiology and cognitive impairment: a narrative review of current clinical literature.BMC anesthesiology · 2019Review
- Current Perspectives on Postoperative Cognitive Dysfunction in the Ageing Population.Turkish journal of anaesthesiology and reanimation · 2019Review
- Cognitive function after surgery with regional or general anesthesia: A population-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concerns have been raised about the effects on cognition of anaesthesia for surgery, especially in elderly people. We recorded cognitive decline in a cohort of 394 people (198 women) with median (IQR) age at recruitment of 72.6 (66.6-77.8) years, of whom 109 had moderate or major surgery during a median (IQR) follow-up of 4.1 (2.0-7.6) years. Cognitive decline was more rapid in people who on recruitment were: older, p = 0.0003; male, p = 0.027; had worse cognition, p < 0.0001; or carried the ε4 allele of apoliprotein E (APOEε4), p = 0.008; and after an operation if cognitive impairment was already diagnosed, p = 0.0001. Cognitive decline appears to accelerate after surgery in elderly patients diagnosed with cognitive impairment, but not other elderly patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.