Evidence map›Paper›PMID 27501109›Full record

ArticleJournal of occupational and environmental medicine2016

MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans.

Collynn F Woeller, Thomas H Thatcher, Daniel Van Twisk, Stephen J Pollock, Amanda Croasdell, Philip K Hopke, Xiaoyan Xia, Juilee Thakar, Patricia J Sime, Timothy M Mallon and 2 more

Abstract read
In one paragraph

Article in Journal of occupational and environmental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Occupational Exposures and Environmental Health Hazards of Military Personnel.International journal of environmental research and public health · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Environmental Chemicals Altered in Association With Deployment for High Risk Areas.Journal of occupational and environmental medicine · 2019
    Article
  11. Metabolome-Wide Association Study of Deployment to Balad, Iraq or Bagram, Afghanistan.Journal of occupational and environmental medicine · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. MicroRNA Changes in Firefighters.Journal of occupational and environmental medicine · 2018
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Collynn F WoellerDepartment of Environmental Medicine (Dr Woeller, Mr Pollock, Ms Croasdell, Dr Sime, Dr Utell, and Dr Phipps), Department of Medicine (Dr Thatcher, Dr Sime, Dr Utell, and Dr Phipps), Microbiology and Immunology (Mr Van Twisk, Dr Thakar, and Dr Phipps), and Department of Biostatistics and Computational Biology (Mr Van Twisk, Dr Thakar), University of Rochester Medical Center; Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Dr Hopke, Dr Xia); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon).
Thomas H Thatcher
Daniel Van Twisk
Stephen J Pollock
Amanda Croasdell
Philip K Hopke
Xiaoyan Xia
Juilee Thakar
Patricia J Sime
Timothy M Mallon
Mark J Utell
Richard P Phipps

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Training in Environment ToxicologyT32ES007026 · NIEHS · UNIVERSITY OF ROCHESTER · PI Alison Elder, Marissa Sobolewski Terry · 1985 to 2026
$20.2M
NIEHS NIH HHS P30 ES001247NIEHS NIH HHS T32 ES007026
6 · The paper itself

Abstract

objectiveTo determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared with length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs).

methodsMiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlations between serum miRNA and PCDD/PCDFs were assessed with a linear regression model.

resultsSeveral miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified.

conclusionsSerum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.

Indexed as

Military PersonnelAir Pollutants, OccupationalBiomarkersDibenzofurans, PolychlorinatedEnvironmental ExposureEnvironmental MonitoringHumansIncinerationMicroRNAsOccupational ExposurePolychlorinated DibenzodioxinsAir Pollutants, OccupationalBiomarkersDibenzofurans, PolychlorinatedMicroRNAsPolychlorinated Dibenzodioxins

Identifiers

PMID27501109
PMCPMC4978134

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.