ArticlePloS one2016
Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Safety and efficacy of AK0529 in respiratory syncytial virus-infected infant patients: A phase 2 proof-of-concept trial.Influenza and other respiratory viruses · 2023Trial
- Misdiagnosis of bronchiolitis and misuse of antibiotics - experience from the largest paediatric hospital of Bangladesh.Journal of global health · 2026Observational
- The prevalence and role of human respiratory syncytial virus in pediatric respiratory tract infections: a systematic review and meta-analysis of global data.EClinicalMedicine · 2026Article
- Research on age-stratified prevention and control strategies for pediatric RSV infection based on disease burden disparities.BMC infectious diseases · 2026Article
- Epidemiology and clinical impact of pediatric RSV co-infections after the COVID-19 pandemic: a narrative review.Frontiers in pediatrics · 2026Review
- Respiratory syncytial virus hospitalization costs, rates, and seasonality in Asia: a systematic review and meta-analysis.EClinicalMedicine · 2025Review
- Article
- Article
- Estimating the economic burden of respiratory syncytial virus infections in infants in Vietnam: a cohort study.BMC infectious diseases · 2023Article
- Hepatic involvement in children with acute bronchiolitis.World journal of hepatology · 2022Article
- Viral burden and diversity in acute respiratory tract infections in hospitalized children in wet and dry zones of Sri Lanka.PloS one · 2021Article
- Respiratory viruses in individuals with a high frequency of animal exposure in southern and highland Vietnam.Journal of medical virology · 2020Article
- Respiratory Syncytial Virus Disease Severity Is Associated with Distinct CD8American journal of respiratory and critical care medicine · 2020Article
- Respiratory Syncytial Virus Seasonality, Beijing, China, 2007-2015.Emerging infectious diseases · 2019Article
- The Impact of RSV-Associated Respiratory Disease on Children in Asia.Journal of pediatric infectious diseases · 2019Review
- Observational
- Article
- Clinical and Molecular Epidemiology of Human Parainfluenza Viruses 1-4 in Children from Viet Nam.Scientific reports · 2018Article
- Enterovirus serotypes in patients with central nervous system and respiratory infections in Viet Nam 1997-2010.Virology journal · 2018Article
- DETECTION OF NON-INFLUENZA VIRUSES IN ACUTE RESPIRATORY INFECTIONS IN CHILDREN UNDER FIVE-YEAR-OLD IN COTE D'IVOIRE (JANUARY - DECEMBER 2013).African journal of infectious diseases · 2018Article
Corrections and comments
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Authors and funding
23 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundDespite a high burden of respiratory syncytial virus (RSV) infections among children, data on demographic and clinical characteristics of RSV are scarce in low and middle income countries. This study aims to describe the viral etiologies, the demographic, epidemiological, and clinical characteristics of children under two years of age who were hospitalized with a lower respiratory tract infections (LRTI), focusing on RSV (prevalence, seasonality, subgroups, viral load) and its association with disease severity.
methodsA prospective study among children under two years of age, hospitalized with LRTI was conducted in two referral pediatric hospitals in Ho Chi Minh City, Vietnam, from May 2009 to December 2010. Socio-demographic, clinical data and nasopharyngeal swabs were collected on enrolment and discharge. Multiplex real-time RT-PCR (13 viruses) and quantitative RSV RT-PCR were used to identify viral pathogens, RSV load and subgroups.
resultsAmong 632 cases, 48% were RSV positive. RSV infections occurred at younger age than three other leading viral infections i.e rhinovirus (RV), metapneumovirus (MPV), parainfluenza virus (PIV-3) and were significantly more frequent in the first 6 months of life. Clinical severity score of RSV infection was significantly higher than PIV-3 but not for RV or MPV. In multivariate analysis, RV infection was significantly associated with severity while RSV infection was not. Among RSV infections, neither viral load nor viral co-infections were significantly associated with severity. Young age and having fever at admission were significantly associated with both RSV and LRTI severity. A shift in RSV subgroup predominance was observed during two consecutive rainy seasons but was not associated with severity.
conclusionWe report etiologies, the epidemiological and clinical characteristics of LRTI among hospitalized children under two years of age and risk factors of RSV and LRTI severity.
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