ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2017
Autologous tendon-derived cell-seeded nanofibrous scaffolds improve rotator cuff repair in an age-dependent fashion.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- [Key role of biomechanical properties and material selection in rotator cuff repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Innovative Nanotechnological Approaches in Trauma and Orthopaedic Surgery: A Comprehensive Review.Cureus · 2024Review
- Nanotechnology development in surgical applications: recent trends and developments.European journal of medical research · 2023Review
- Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing.Connective tissue research · 2023Review
- Advances toward transformative therapies for tendon diseases.Science translational medicine · 2022Review
- Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies.Bioactive materials · 2022Article
- The Role of Nanomaterials and Biological Agents on Rotator Cuff Regeneration.Regenerative engineering and translational medicine · 2021Article
- Injection of Micronized Human Amnion/Chorion Membrane Results in Increased Early Supraspinatus Muscle Regeneration in a Chronic Model of Rotator Cuff Tear.Annals of biomedical engineering · 2021Article
- Localized delivery of ibuprofen via a bilayer delivery system (BiLDS) for supraspinatus tendon healing in a rat model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells.Biofabrication · 2019Article
- Evaluation of microstructurally motivated constitutive models to describe age-dependent tendon healing.Biomechanics and modeling in mechanobiology · 2018Article
- Regenerative Engineering of the Rotator Cuff of the Shoulder.ACS biomaterials science & engineering · 2018Article
- Nanotechnology in orthopedics: a clinically oriented review.BMC musculoskeletal disorders · 2018Review
- Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
Rotator cuff tendon tears are one of the most common shoulder pathologies, especially in the aging population. Due to a poor healing response and degenerative changes associated with aging, rotator cuff repair failure remains common. Although cell-based therapies to augment rotator cuff repair appear promising, it is unknown whether the success of such a therapy is age-dependent. We hypothesized that autologous cell therapy would improve tendon-to-bone healing across age groups, with autologous juvenile cells realizing the greatest benefit. In this study, juvenile, adult, and aged rats underwent bilateral supraspinatus tendon repair with augmentation of one shoulder with autologous tendon-derived cell-seeded polycaprolactone scaffolds. At 8 weeks, shoulders treated with cells in both juvenile and aged animals exhibited increased cellularity, increased collagen organization, and improved mechanical properties. No changes between treated and control limbs were seen in adult rats. These findings suggest that cell delivery during supraspinatus repair initiates earlier matrix remodeling in juvenile and aged animals. This may be due to the relative "equilibrium" of adult tendon tissue with regards to catabolic and anabolic processes, contrasted with actively growing juvenile tendons and degenerative aged tendons. This study demonstrates the potential for autologous cell-seeded scaffolds to improve repairs in both the juvenile and aged population. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1250-1257, 2017.
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