ArticlePLoS genetics2016
Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Tumour-driven lipid accumulation in oenocytes reflects systemic lipid alterations.PLoS genetics · 2026Article
- NF-κB-mediated developmental delay extends lifespan inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Regulatory changes in the fatty acid elongase eloF underlie the evolution of sex-specific pheromone profiles in Drosophila prolongata.BMC biology · 2025Article
- Multiple factors contribute to female dominance in migratory bioflows.Open biology · 2025Article
- Whole organism and tissue-specific analysis of pexophagy inOpen biology · 2025Article
- Regulatory Changes in the Fatty Acid ElongasebioRxiv : the preprint server for biology · 2024Article
- Insect hormone PTTH regulates lifespan through temporal and spatial activation of NF-κB signaling during metamorphosis.bioRxiv : the preprint server for biology · 2024Article
- Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.Science advances · 2023Article
- Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte nuclear factor 4.bioRxiv : the preprint server for biology · 2023Article
- Symbiosis preservation: Putative regulation of fatty acyl-CoA reductase by miR-31a within the symbiont harboring bacteriome through tsetse evolution.Frontiers in microbiology · 2023Article
- Communal living: the role of polyploidy and syncytia in tissue biology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Review
- Advances in deciphering the genetic basis of insect cuticular hydrocarbon biosynthesis and variation.Heredity · 2021Review
- Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila.Genome biology and evolution · 2019Article
- Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood.Developmental cell · 2019Article
- RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress.BMC genomics · 2019Article
- Developmental diet regulates Drosophila lifespan via lipid autotoxins.Nature communications · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Cell growth and proliferation depend upon many different aspects of lipid metabolism. One key signaling pathway that is utilized in many different anabolic contexts involves Phosphatidylinositide 3-kinase (PI3K) and its membrane lipid products, the Phosphatidylinositol (3,4,5)-trisphosphates. It remains unclear, however, which other branches of lipid metabolism interact with the PI3K signaling pathway. Here, we focus on specialized fat metabolizing cells in Drosophila called larval oenocytes. In the presence of dietary nutrients, oenocytes undergo PI3K-dependent cell growth and contain very few lipid droplets. In contrast, during starvation, oenocytes decrease PI3K signaling, shut down cell growth and accumulate abundant lipid droplets. We now show that PI3K in larval oenocytes, but not in fat body cells, functions to suppress lipid droplet accumulation. Several enzymes of fatty acid, triglyceride and hydrocarbon metabolism are required in oenocytes primarily for lipid droplet induction rather than for cell growth. In contrast, a very long chain fatty-acyl-CoA reductase (FarO) and a putative lipid dehydrogenase/reductase (Spidey, also known as Kar) not only promote lipid droplet induction but also inhibit oenocyte growth. In the case of Spidey/Kar, we show that the growth suppression mechanism involves inhibition of the PI3K signaling pathway upstream of Akt activity. Together, the findings in this study show how Spidey/Kar and FarO regulate the balance between the cell growth and lipid storage of larval oenocytes.
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