ArticleJournal of the American Chemical Society2016
Nucleophilic (Radio)Fluorination of α-Diazocarbonyl Compounds Enabled by Copper-Catalyzed H-F Insertion.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Nitrosoarenes as Versatile Precursors forACS omega · 2026Article
- Distinct hydrogen atom transfer and radical capture reactivity of copper(iii) OH/F complexes enables site-selective C(spChemical science · 2026Article
- Hexafluoroisopropanol Solvent Effects on Enantioselectivity of Dirhodium Tetracarboxylate-Catalyzed Cyclopropanation.Journal of the American Chemical Society · 2025Article
- Zinc-Mediated Radiosynthesis of Unprotected Fluorine-18 Labelled α-Tertiary Amides.Angewandte Chemie (International ed. in English) · 2024Article
- Deoxyfluorination of phenols for chemoselectiveNature protocols · 2023Review
- Hydrogen Bonding Phase-Transfer Catalysis with Alkali Metal Fluorides and Beyond.Journal of the American Chemical Society · 2022Article
- Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design.Frontiers in chemistry · 2022Review
- Uncommon carbene insertion reactions.Chemical science · 2021Review
- Closing the gap betweenEJNMMI radiopharmacy and chemistry · 2021Review
- Asymmetric synthesis of pharmaceutically relevant 1-aryl-2-heteroaryl- and 1,2-diheteroarylcyclopropane-1-carboxylates.Chemical science · 2021Article
- Copper-Mediated Late-stage Radiofluorination: Five Years of Impact on Pre-clinical and Clinical PET Imaging.Clinical and translational imaging · 2020Article
- Article
- Photoinduced Proton-Transfer Reactions for Mild O-H Functionalization of Unreactive Alcohols.Angewandte Chemie (International ed. in English) · 2020Article
- Catalytic Asymmetric Fluorination of Copper Carbene Complexes: Preparative Advances and a Mechanistic Rationale.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Synthesis of [Synthesis · 2019Article
- (Radio)fluoroclick Reaction Enabled by a Hydrogen-Bonding Cluster.Angewandte Chemie (International ed. in English) · 2018Article
- Enantiospecific Solvolytic Functionalization of Bromochlorides.Journal of the American Chemical Society · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
The copper-catalyzed H-F insertion into α-diazocarbonyl compounds is described using potassium fluoride (KF) and hexafluoroisopropanol. Access to complex α-fluorocarbonyl derivatives is achieved under mild conditions, and the method is readily adapted to radiofluorination with [(18)F]KF. This late-stage strategy provides an attractive route to (18)F-labeled biomolecules.
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