Evidence map›Paper›PMID 27500181›Full record

ArticleMovement disorders clinical practice

Amyloid-Beta Positron Emission Tomography Imaging of Alzheimer's Pathology in Parkinson's Disease Dementia.

Rizwan S Akhtar, Sharon X Xie, Laura Brennan, Michael J Pontecorvo, Howard I Hurtig, John Q Trojanowski, Daniel Weintraub, Andrew D Siderowf

Open access · greenAbstract read
In one paragraph

Article in Movement disorders clinical practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Morphological basis of Parkinson disease-associated cognitive impairment: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. The seed ofPharmaceutical biology · 2020
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Gray/White Matter Contrast in Parkinson's Disease.Frontiers in aging neuroscience · 2018
    Article
  20. Cognitive decline in Parkinson disease.Nature reviews. Neurology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rizwan S AkhtarDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA; Center for Neurodegenerative Disease Research and Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA.
Sharon X XieDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA.
Laura BrennanDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA; Department of Psychiatry, Perelman School of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA.
Michael J PontecorvoAvid Radiopharmaceuticals, Philadelphia, PA 19104, USA.
Howard I HurtigDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA.
John Q TrojanowskiCenter for Neurodegenerative Disease Research and Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA.
Daniel WeintraubDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA; Department of Psychiatry, Perelman School of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA.
Andrew D SiderowfDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-3339, USA; Avid Radiopharmaceuticals, Philadelphia, PA 19104, USA.
University of Pennsylvania · US

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1M
Project IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9M
TDP-43 Proteinopathies in ALS-DementiaP01AG032953 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2010 to 2014
$5.8M
Alpha-synuclein biomarkers in Parkinson diseaseK08NS093127 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AKHTAR, RIZWAN SMEER · 2015 to 2019
$918k
NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG032953NIA NIH HHS P30 AG010124NINDS NIH HHS K08 NS093127NINDS NIH HHS P50 NS053488
6 · The paper itself

Abstract

backgroundNeuronal loss and α-synuclein (α-syn) pathology are diagnostic of PD in the appropriate clinical context. However, some PD patients have co-morbid Alzheimer's disease (AD) pathology on autopsy, including amyloid-β (Aβ) plaques and neurofibrillary tangles. Florbetapir(

objectiveTo determine the utility of florbetapir(

methodsFive participants with PDD had florbetapir(

resultsAll participants met neuropathological criteria for PD. Two had both positive florbetapir(

conclusionsFlorbetapir(

Indexed as

autopsyneurodegenerationNeuroimagingparkinsonismtauopathy

Identifiers

PMID27500181
PMCPMC4971540
OpenAlexW2238381287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.