Evidence map›Paper›PMID 27500128›Full record

ArticleNorth American journal of medical sciences2016

Cardiovascular Responses to an Isometric Handgrip Exercise in Females with Prehypertension.

Vernon Bond, Bryan H Curry, Richard G Adams, Thomas Obisesan, Sudhakar Pemminati, Vasavi R Gorantla, Kishan Kadur, Richard M Millis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in North American journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Vernon BondDepartment of Recreation, Human Performance and Leisure Studies and Exercise Science and Human Nutrition Laboratory, Howard University Cancer Centre, Washington DC, USA.
Bryan H CurryDepartment of Medicine, Division of Cardiology, Howard College of Medicine and Howard University Hospital, Washington DC, USA.
Richard G AdamsDepartment of Internal Medicine, Howard University Hospital, Washington DC, USA.
Thomas ObisesanDepartment of Internal Medicine, Howard University Hospital, Washington DC, USA.
Sudhakar PemminatiDepartment of Medical Pharmacology, AUA College of Medicine, Antigua and Barbuda, and Manipal University, Manipal, Karnataka, India.
Vasavi R GorantlaDepartment of Behavioural Sciences and Neuroscience, AUA College of Medicine, Antigua and Barbuda.
Kishan KadurDepartment of Medical Physiology, AUA College of Medicine, Antigua and Barbuda.
Richard M MillisDepartment of Medical Physiology, AUA College of Medicine, Antigua and Barbuda.
American University of Antigua · AGHoward University Hospital · USHoward College · USHoward University · USManipal Academy of Higher Education · IN

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
NCATS NIH HHS UL1 TR001409NIMHD NIH HHS G12 MD007597
6 · The paper itself

Abstract

backgroundHypertensive individuals are known to exhibit greater increases in blood pressure during an isometric handgrip exercise (IHE) than their normotensive counterparts.

aimThis study tests the hypothesis that, compared to normotensive individuals, prehypertensive individuals exhibit an exaggerated response to IHE. MATERIALS AND

methodsIn this study, the effects of IHE were compared in matched prehypertensive vs. normotensive healthy African-American females. Six healthy young adult African-American female university students were screened in a physician's office for blood pressure in the range of prehypertension, systolic blood pressure (SBP) 120-139 mmHg and diastolic blood pressure (DBP) 80-89 mmHg. Six young adult African-American women were also recruited to serve as a healthy normotensive control group with SBP ≤119 mmHg and DBP ≤79 mmHg. Cardiovascular fitness was determined by peak oxygen uptake (VO2 peak) measured during a progressive exercise test.

resultsDuring the handgrip exercise, the prehypertensive group exhibited greater increases in SBP (from 139 ± 6 to 205 ± 11 mmHg, +48%) than the controls (from 132 ± 3 to 145 ± 3 mmHg, +10%); intergroup difference P < 0.001. The prehypertensive group also exhibited greater increases in DBP (from 77 ± 2 to 112 ± 5 mmHg, +46%) compared to the controls (from 72 ± 3 to 78 ± 4 mmHg, +8%); intergroup difference P < 0.001. The increase in systemic vascular resistance was also greater in the prehypertensive group (from 1713 ± 91 to 2807 ± 370 dyne.s.cm(-5), +64%) than in the controls (from 1668 ± 80 to 1812 ± 169 dyne.s.cm(-5), +9%); intergroup difference P < 0.05.

conclusionThese results suggest that blood pressure measurements performed during IHE may be a useful screening tool in evaluating prehypertensive individuals for antihypertensive treatments.

Indexed as

Arterial complianceblood pressureheart ratemyocardial oxygen demandsystemic vascular resistance

Identifiers

PMID27500128
PMCPMC4960933
OpenAlexW2461142405

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.