Evidence map›Paper›PMID 27500074›Full record

ArticleRare diseases (Austin, Tex.)2016

Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases.

Moones Heidari, Sam H Gerami, Brianna Bassett, Ross M Graham, Anita C G Chua, Ritambhara Aryal, Michael J House, Joanna F Collingwood, Conceição Bettencourt, Henry Houlden and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rare diseases (Austin, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Moones HeidariSchool of Biomedical Sciences and Pharmacy, The University of Newcastle , Callaghan, NSW, Australia.
Sam H GeramiSchool of Biomedical Sciences and Pharmacy, The University of Newcastle , Callaghan, NSW, Australia.
Brianna BassettSchool of Biomedical Sciences and Pharmacy, The University of Newcastle , Callaghan, NSW, Australia.
Ross M GrahamSchool of Biomedical Sciences & Curtin Health Innovation Research Institute - Biosciences, Curtin University of Technology , Bentley, WA, Australia.
Anita C G ChuaSchool of Medicine and Pharmacology, University of Western Australia, Fiona Stanley Hospital, Murdoch, WA, Australia; Harry Perkins Institute of Medical Research, Murdoch, WA, Australia.
Ritambhara AryalSchool of Biomedical Sciences and Pharmacy, The University of Newcastle , Callaghan, NSW, Australia.
Michael J HouseSchool of Physics, University of Western Australia , Crawley, WA, Australia.
Joanna F CollingwoodWarwick Engineering in Biomedicine, School of Engineering, University of Warwick , Coventry, UK.
Conceição BettencourtDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Henry HouldenDepartment of Molecular Neuroscience, UCL Institute of Neurology , London, UK.
Mina RytenDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical and Molecular Genetics, King's College London, London, UK.
UK Brain Expression Consortium (UKBEC)
John K OlynykSchool of Biomedical Sciences & Curtin Health Innovation Research Institute - Biosciences, Curtin University of Technology, Bentley, WA, Australia; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia; Department of Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch, WA, Australia; Department of Gastroenterology and Hepatology, Fremantle Hospital, Fremantle, WA, Australia.
Debbie TrinderSchool of Medicine and Pharmacology, University of Western Australia, Fiona Stanley Hospital, Murdoch, WA, Australia; Harry Perkins Institute of Medical Research, Murdoch, WA, Australia.
Daniel M JohnstoneBosch Institute and Discipline of Physiology, University of Sydney , Sydney, NSW, Australia.
Elizabeth A MilwardSchool of Biomedical Sciences and Pharmacy, The University of Newcastle , Callaghan, NSW, Australia.
University of Newcastle Australia · AUUniversity College London · GBFiona Stanley Hospital · AUCurtin University · AUFremantle Hospital · AURobert Bosch (Australia) · AUUniversity of Warwick · GBUniversity of Western Australia · AU

Funding

Medical Research Council G0802462Medical Research Council G0802760Medical Research Council G1001253Medical Research Council G108/638Medical Research Council MR/J004758/1Medical Research Council MR/K01417X/1Medical Research Council MR/N008324/1
6 · The paper itself

Abstract

We previously demonstrated elevated brain iron levels in myelinated structures and associated cells in a hemochromatosis Hfe (-/-) xTfr2 (mut) mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family 'neurodegeneration with brain iron accumulation' (NBIA). Expanded data mining and ontological analyses have now identified additional myelin-related transcriptome changes in response to brain iron loading. Concordance between the mouse transcriptome changes and human myelin-related gene expression networks in normal and NBIA basal ganglia testifies to potential clinical relevance. These analyses implicate, among others, genes linked to various rare central hypomyelinating leukodystrophies and peripheral neuropathies including Pelizaeus-Merzbacher-like disease and Charcot-Marie-Tooth disease as well as genes linked to other rare neurological diseases such as Niemann-Pick disease. The findings may help understand interrelationships of iron and myelin in more common conditions such as hemochromatosis, multiple sclerosis and various psychiatric disorders.

Indexed as

arraybrainhemochromatosisironmyelinNBIAneurodegenerationoligodendrocyte

Identifiers

PMID27500074
PMCPMC4961263
OpenAlexW2472717928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.