ArticleJournal of thoracic disease2016
A systematic review and meta-analysis-does chronic obstructive pulmonary disease predispose to bronchopleural fistula formation in patients undergoing lung cancer surgery?
Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Surgical strategy for closure of postoperative bronchopleural fistula: a narrative review.Journal of thoracic disease · 2026Review
- Chinese expert consensus on the diagnosis and management of bronchopleural fistula after pulmonary resection (2026 edition).Journal of thoracic disease · 2026Review
- Free pericardial fat pad for covering bronchial stump after thoracoscopic lobectomy: a sutureless method.Indian journal of thoracic and cardiovascular surgery · 2025Article
- Bronchopleural fistula following application of Hem-o-lock clip at bronchial stump after lobectomy: A case report.World journal of clinical cases · 2025Article
- Bronchopleural fistula after lobectomy: who is at risk in the modern era?Journal of thoracic disease · 2023Article
- Risk factors for bronchopleural fistula after lobectomy for lung cancer.Journal of thoracic disease · 2023Article
- Development of Bronchopleural Fistula Complicated by Empyema Fifteen Years After Right Lower Lobe Lobectomy: A Case Report.The American journal of case reports · 2020Article
- A Stepwise Approach for Postlobectomy Bronchopleural Fistula.Operative techniques in thoracic and cardiovascular surgery : a comparative atlas : an official publication of the American Association for Thoracic Surgery · 2020Article
- Presence of pleural adhesions can predict conversion to thoracotomy and postoperative surgical complications in patients undergoing video-assisted thoracoscopic lung cancer lobectomy.Journal of thoracic disease · 2018Article
- Effects of degree of pulmonary fissure completeness on major in-hospital outcomes after video-assisted thoracoscopic lung cancer lobectomy: a retrospective-cohort study.Therapeutics and clinical risk management · 2018Article
- Risk factor of bronchopleural fistula after general thoracic surgery: review article.General thoracic and cardiovascular surgery · 2017Review
- Positive pressure ventilation in a patient with a right upper lobar bronchocutaneous fistula: right upper bronchus occlusion using the cuff of a left-sided double lumen endobronchial tube.Journal of anesthesia · 2017Article
- Article
- Chronic obstructive pulmonary disease in patients with lung cancer: prevalence, impact and management challenges.Lung Cancer (Auckland, N.Z.) · 2017Review
- Enhanced recovery programs in lung cancer surgery: systematic review and meta-analysis of randomized controlled trials.Cancer management and research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundwe conducted this systematic meta-analysis to determine the association between chronic obstructive pulmonary disease (COPD) and risk of bronchopleural fistula (BPF) in patients undergoing lung cancer surgery.
methodsLiterature retrieval was performed in PubMed, Embase and the Web of Science to identify the full-text articles that met our eligibility criteria. Odds ratio (OR) with 95% confidence interval (CI) served as the summarized statistics. Q-test and I(2)-statistic were used to evaluate the level of heterogeneity. Sensitivity analysis was performed to further examine the stability of pooled OR. Publication bias was detected by both Begg's test and Egger's test.
resultsEight retrospective observational studies were included into this meta-analysis. The overall summarized OR was 2.03 (95% CI: 1.44-2.86; P<0.001), revealing that COPD was significantly associated with the risk of BPF after lung cancer surgery. In subgroup analysis, the relationship between COPD and BPF occurrence remained statistically prominent in the subgroups stratified by statistical analysis (univariate analysis, OR: 1.91; 95% CI: 1.35-2.69; P<0.001; multivariate analysis, OR: 3.18; 95% CI: 1.95-5.19; P<0.001), operative modes (pneumonectomy, OR: 2.11; 95% CI: 1.15-3.87; P=0.016) and in non-Asian populations (OR: 2.36; 95% CI: 1.18-4.73; P=0.016). No significant impact of COPD on BPF risk was observed in Asian patients (OR: 1.48; 95% CI: 0.85-2.57; P=0.16). No significant heterogeneity or publication bias was discovered across the included studies.
conclusionsOur meta-analysis indicates that COPD can significantly predispose to BPF formation in patients undergoing lung cancer surgery. Because some limitations still exist in this meta-analysis, our findings should be further verified and modified in the future.
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