ArticleJournal of thoracic disease2016
Strong correlation between lung ultrasound and chest computerized tomography imaging for the detection of acute lung injury/acute respiratory distress syndrome in rats.
Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 10 citations in OpenAlex.
- Comparison of Postoperative Oxygenation and Dorsal Lung Ventilation in Patients Undergoing Craniotomy in Different Positions: Pulmonary Electrical Impedance Tomography Monitoring.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Disease landscape-guided design of neutrophil-specific reporters for early and accurate pneumonia detection in vivo and in urine.Science advances · 2026Article
- Imaging in animal models: bridging experimental findings and human pathophysiology.Critical care (London, England) · 2025Review
- Diagnostic Accuracy of Lung Ultrasound in Rabbit Subclinical Lung Lesions.Veterinary sciences · 2025Article
- The Rat Thoracic Ultrasound protocol: scanning technique and normal findings.Frontiers in veterinary science · 2024Article
- Advanced development and mechanism of sepsis-related acute respiratory distress syndrome.Frontiers in medicine · 2022Review
- From bedside to bench: lung ultrasound for the assessment of pulmonary edema in animal models.Cell and tissue research · 2020Review
- Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis.PloS one · 2020Article
- In Vivo Endomicroscopy of Lung Injury and Repair in ARDS: Potential Added Value to Current Imaging.Journal of clinical medicine · 2019Review
- Diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome.BMC pulmonary medicine · 2018Article
- ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS).Advances in experimental medicine and biology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung ultrasound (LUS) is a clinical imaging technique for diagnosing acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In humans and several large animals, LUS demonstrates similar specificity and sensitivity to computerized tomography (CT) scanning. Current study evaluated the degree of agreement between LUS and CT imaging in characterizing ALI/ARDS in rats.
methodsThirty male Sprague-Dawley rats were imaged by LUS before randomization into three groups to receive intratracheal saline, 3 or 6 mg/kg LPS respectively (n=10). LUS and CT imaging was conducted 2 hours after instillation. Cross table analyses and kappa statistics were used to determine agreement levels between LUS and CT assessments of lung condition.
resultsBefore instillation, rats presented with a largely A-pattern in LUS images, however, a significantly increase B-lines were observed in all groups after instillation and showed dose response to LPS or to saline. One rat treated with 6 mg/kg lipopolysaccharide (LPS) presented with lung consolidation. The agreement between the LUS and the CT in detecting the main characteristics of ALI/ARDS in rat was strong (r=0.758, P<0.01, k=0.737).
conclusionsIn conclusion, LUS detects ALI/ARDS with high agreement with micro PET/CT scanning in a rat model, suggesting that LUS represents a positive refinement in rat ALI/ARDS disease models.
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