ReviewRegeneration (Oxford, England)2016
The relationship between growth and pattern formation.
Review in Regeneration (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Stress anisotropy in confined populations of growing rods.Journal of the Royal Society, Interface · 2022Article
- Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering.eLife · 2021Article
- Identification of Heparan-Sulfate Rich Cells in the Loose Connective Tissues of the Axolotl (Ambystoma mexicanum) with the Potential to Mediate Growth Factor Signaling during Regeneration.Regenerative engineering and translational medicine · 2020Article
- The VACTERL association: mosaic mitotic aneuploidy as a cause and a model.Journal of assisted reproduction and genetics · 2019Review
- Exogenous Vitamin D signaling alters skeletal patterning, differentiation, and tissue integration during limb regeneration in the axolotl.Mechanisms of development · 2018Article
- Transcriptional correlates of proximal-distal identify and regeneration timing in axolotl limbs.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2018Article
- Engineering multicellular systems: using synthetic biology to control tissue self-organization.Current opinion in biomedical engineering · 2017Article
- Regulation of regeneration by Heparan Sulfate Proteoglycans in the Extracellular Matrix.Regenerative engineering and translational medicine · 2017Article
- The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche.Current stem cell reports · 2017Article
- Mechanisms of urodele limb regeneration.Regeneration (Oxford, England) · 2017Review
- Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action.eLife · 2017Article
- Zebrafish fin regeneration after cryoinjury-induced tissue damage.Biology open · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful development depends on the creation of spatial gradients of transcription factors within developing fields, and images of graded distributions of gene products populate the pages of developmental biology journals. Therefore the challenge is to understand how the graded levels of intracellular transcription factors are generated across fields of cells. We propose that transcription factor gradients are generated as a result of an underlying gradient of cell cycle lengths. Very long cell cycles will permit accumulation of a high level of a gene product encoded by a large transcription unit, whereas shorter cell cycles will permit progressively fewer transcripts to be completed due to gating of transcription by the cell cycle. We also propose that the gradients of cell cycle lengths are generated by gradients of extracellular morphogens/growth factors. The model of cell cycle gated transcriptional regulation brings focus back to the functional role of morphogens as cell cycle regulators, and proposes a specific and testable mechanism by which morphogens, in their roles as growth factors (how they were originally discovered), also determine cell fate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.