ReviewRegeneration (Oxford, England)2016
Planarian brain regeneration as a model system for developmental neurotoxicology.
Review in Regeneration (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 88 citations in OpenAlex.
- Retention and Distribution of Dopamine-Dependent Reward Memory in Regenerating Planaria.Biomolecules · 2026Article
- Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals.Neurotoxicology · 2026Article
- Viability ofmicroPublication biology · 2026Article
- Microbiome Alteration Prevents Abstinence-Induced Nicotine Withdrawal in a Well-Established Planarian Model.Cureus · 2025Article
- Impact of host physiology and external stressors on the bacterial community of Schmidtea mediterranea.Scientific reports · 2025Article
- Exploring the potential ofCurrent research in toxicology · 2025Article
- Effects of melatonin on planaria head regeneration are dependent on both timing and duration of exposure.Physiological reports · 2025Article
- Planarian Mucus: A Novel Source of Pleiotropic Cytotoxic and Cytostatic Agents against Cancer Cells.Biomolecules · 2024Article
- Article
- A Simple Method for Quantifying Blastema Growth in Regenerating Planarians.Current protocols · 2023Article
- Use of invertebrates to model chemically induced parkinsonism-symptoms.Biochemical Society transactions · 2023Review
- Comparative toxicity assessment of glyphosate and two commercial formulations in the planarianFrontiers in toxicology · 2023Article
- Synthesis of Methacryloylated Hydroxyethylcellulose and Development of Mucoadhesive Wafers for Buccal Drug Delivery.Polymers · 2022Article
- New Worm on the Block: Planarians in (Neuro)Toxicology.Current protocols · 2022Article
- Bioactivation and detoxification of organophosphorus pesticides in freshwater planarians shares similarities with humans.Archives of toxicology · 2022Article
- Molecular characterization of a flatworm Girardia isolate from Guanajuato, Mexico.Developmental biology · 2022Article
- Differences in neurotoxic outcomes of organophosphorus pesticides revealedFrontiers in toxicology · 2022Article
- A locust embryo as predictive developmental neurotoxicity testing system for pioneer axon pathway formation.Archives of toxicology · 2020Article
- Dugesia japonica is the best suited of three planarian species for high-throughput toxicology screening.Chemosphere · 2020Article
- Scanning laser optical tomography resolves developmental neurotoxic effects on pioneer neurons.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Freshwater planarians, famous for their regenerative prowess, have long been recognized as a valuable in vivo animal model to study the effects of chemical exposure. In this review, we summarize the current techniques and tools used in the literature to assess toxicity in the planarian system. We focus on the planarian's particular amenability for neurotoxicology and neuroregeneration studies, owing to the planarian's unique ability to regenerate a centralized nervous system. Zooming in from the organismal to the molecular level, we show that planarians offer a repertoire of morphological and behavioral readouts while also being amenable to mechanistic studies of compound toxicity. Finally, we discuss the open challenges and opportunities for planarian brain regeneration to become an important model system for modern toxicology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.