ArticleRegeneration (Oxford, England)2016
Analogous cellular contribution and healing mechanisms following digit amputation and phalangeal fracture in mice.
Article in Regeneration (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Digit regeneration in mice is stimulated by sequential treatment with FGF2 and BMP2.Nature communications · 2026Article
- Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation.The Journal of clinical investigation · 2026Article
- Mouse digit AAV gene delivery into fibroblasts regulates regenerative outcome.Science advances · 2026Article
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- Osteoprogenitor cells from non-regenerative bone show greater resistance to cellular stress than those from regenerative bone.Frontiers in cell and developmental biology · 2025Article
- Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart.Developmental biology · 2024Review
- Induced regeneration of articular cartilage - identification of a dormant regeneration program for a non-regenerative tissue.Development (Cambridge, England) · 2023Article
- Deer antler renewal gives insights into mammalian epimorphic regeneration.Cell regeneration (London, England) · 2023Review
- Toeing the line between regeneration and fibrosis.Frontiers in cell and developmental biology · 2023Review
- To regenerate or not to regenerate: Vertebrate model organisms of regeneration-competency and -incompetency.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Review
- Single-cell mapping of regenerative and fibrotic healing responses after musculoskeletal injury.Stem cell reports · 2022Article
- Low bone mass and impaired fracture healing in mouse models of Trisomy21 (Down syndrome).Bone · 2022Article
- Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook.Cold Spring Harbor perspectives in biology · 2022Review
- Tissue origin of cytotoxic natural killer cells dictates their differential roles in mouse digit tip regeneration and progenitor cell survival.Stem cell reports · 2022Article
- Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine.Development (Cambridge, England) · 2022Article
- Cellular and molecular mechanisms that regulate mammalian digit tip regeneration.Open biology · 2020Article
- BMP9 stimulates joint regeneration at digit amputation wounds in mice.Nature communications · 2019Article
- Digit Tip Regeneration: Merging Regeneration Biology with Regenerative Medicine.Stem cells translational medicine · 2018Article
- Concise Review: Translating Regenerative Biology into Clinically Relevant Therapies: Are We on the Right Path?Stem cells translational medicine · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regeneration of amputated structures is severely limited in humans and mice, with complete regeneration restricted to the distal portion of the terminal phalanx (P3). Here, we investigate the dynamic tissue repair response of the second phalangeal element (P2) post amputation in the adult mouse, and show that the repair response of the amputated bone is similar to the proximal P2 bone fragment in fracture healing. The regeneration-incompetent P2 amputation response is characterized by periosteal endochondral ossification resulting in the deposition of new trabecular bone, corresponding to a significant increase in bone volume; however, this response is not associated with bone lengthening. We show that cells of the periosteum respond to amputation and fracture by contributing both chondrocytes and osteoblasts to the endochondral ossification response. Based on our studies, we suggest that the amputation response represents an attempt at regeneration that ultimately fails due to the lack of a distal organizing influence that is present in fracture healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.