ReviewRegeneration (Oxford, England)2015
Regeneration and repair of human digits and limbs: fact and fiction.
Review in Regeneration (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- MiRNA Atlas: A Literature-Derived Database of MicroRNAs Bridging Osteoarthritis and Appendage Regeneration.bioRxiv : the preprint server for biology · 2026Article
- Bibliometric analysis of limb replantation and transplantation: global research trends and hotspots (2001-2025).Annals of medicine and surgery (2012) · 2026Article
- Neural crest cell recruitment and reprogramming as central drivers of embryonic limb regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sequential Transcutaneous Mechanical Femoral Lengthening of a Profoundly Short Skeletal Residuum and Subsequent Successful Transfemoral Osseointegration: A Case Report Describing a Novel Endo-Exo Intramedullary Stump Lengthening Device.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Transcriptomic landscape around wound bed defines regenerative versus non-regenerative outcomes in mouse digit amputation.PLoS computational biology · 2025Article
- The development of hair follicles and nail.Developmental biology · 2024Review
- Outcomes of Digit Replantation in Children: A Systematic Review.Plastic and reconstructive surgery. Global open · 2023Article
- Semi-occlusive dressing therapy versus surgical treatment in fingertip amputation injuries: a clinical study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Limb blastema formation: How much do we know at a genetic and epigenetic level?The Journal of biological chemistry · 2023Review
- Designing a Biomaterial Approach to Control the Adaptive Response to a Skin Injury.Materials (Basel, Switzerland) · 2022Review
- Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis.Pharmaceutics · 2022Article
- The Contribution of Innervation to Tissue Repair and Regeneration.Cold Spring Harbor perspectives in biology · 2022Article
- Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook.Cold Spring Harbor perspectives in biology · 2022Review
- M2c Macrophages enhance phalange regeneration of amputated mice digits in an organ co-culture system.Iranian journal of basic medical sciences · 2021Article
- Single-cell RNA-seq reveals novel mitochondria-related musculoskeletal cell populations during adult axolotl limb regeneration process.Cell death and differentiation · 2021Article
- Nail matrix regenerative engineering: in vitro evaluation of poly(lactide-co-glycolide)/gelatin fibrous substrates.Journal of biomedical materials research. Part A · 2020Article
- Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms.Stem cells international · 2019Review
- Wound healing, cellular regeneration and plasticity: the elegans way.The International journal of developmental biology · 2018Review
- Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference.Connective tissue research · 2018Article
- Analysis of dermal fibroblasts isolated from neonatal and child cleft lip and adult skin: Developmental implications on reconstructive surgery.International journal of molecular medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of digit and limb repair and reconstruction methods have been used in different clinical settings, but regeneration remains an item on every plastic surgeon's "wish list." Although surgical salvage techniques are continually being improved, unreplantable digits and limbs are still abundant. We comprehensively review the structural and functional salvage methods in clinical practice, from the peeling injuries of small distal fingertips to multisegmented amputated limbs, and the developmental and tissue engineering approaches for regenerating human digits and limbs in the laboratory. Although surgical techniques have forged ahead, there are still situations in which digits and limbs are unreplantable. Advances in the field are delineated, and the regeneration processes of salamander limbs, lizard tails, and mouse digits and each component of tissue engineering approaches for digit- and limb-building are discussed. Although the current technology is promising, there are many challenges in human digit and limb regeneration. We hope this review inspires research on the critical gap between clinical and basic science, and leads to more sophisticated digit and limb loss rescue and regeneration innovations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.