ArticleRegeneration (Oxford, England)2015
Epidermal closure regulates histolysis during mammalian (Mus) digit regeneration.
Article in Regeneration (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
- Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation.The Journal of clinical investigation · 2026Article
- Article
- Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors.bioRxiv : the preprint server for biology · 2025Article
- Article
- Extracellular matrix remodeling supportsbioRxiv : the preprint server for biology · 2025Article
- Aging: the wound that never starts healing.Nature communications · 2025Review
- Silk fibroin hydrogel with recombinant silk fibroin/NT3 protein enhances wound healing by promoting type III collagen synthesis and hair follicle regeneration in skin injury.Materials today. Bio · 2025Article
- Article
- Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart.Developmental biology · 2024Review
- Limb blastema formation: How much do we know at a genetic and epigenetic level?The Journal of biological chemistry · 2023Review
- Toeing the line between regeneration and fibrosis.Frontiers in cell and developmental biology · 2023Review
- Article
- Digit specific denervation does not inhibit mouse digit tip regeneration.Developmental biology · 2022Article
- Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration.eLife · 2022Article
- Mouse Digit Tip Regeneration Is Mechanical Load Dependent.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Mammalian Digit Tip Regeneration: Moving from Phenomenon to Molecular Mechanism.Cold Spring Harbor perspectives in biology · 2022Review
- The Potential of Nail Mini-Organ Stem Cells in Skin, Nail and Digit Tips Regeneration.International journal of molecular sciences · 2021Review
- Tissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms.Frontiers in physiology · 2021Review
- Cellular and molecular mechanisms that regulate mammalian digit tip regeneration.Open biology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian digit regeneration progresses through consistent stages: histolysis, inflammation, epidermal closure, blastema formation, and finally redifferentiation. What we do not yet know is how each stage can affect others. Questions of stage timing, tissue interactions, and microenvironmental states are becoming increasingly important as we look toward solutions for whole limb regeneration. This study focuses on the timing of epidermal closure which, in mammals, is delayed compared to more regenerative animals like the axolotl. We use a standard wound closure device, Dermabond (2-octyl cyanoacrylate), to induce earlier epidermal closure, and we evaluate the effect of fast epidermal closure on histolysis, blastema formation, and redifferentiation. We find that fast epidermal closure is reliant upon a hypoxic microenvironment. Additionally, early epidermal closure eliminates the histolysis stage and results in a regenerate that more closely replicates the amputated structure. We show that tools like Dermabond and oxygen are able to independently influence the various stages of regeneration enabling us to uncouple histolysis, wound closure, and other regenerative events. With this study, we start to understand how each stage of mammalian digit regeneration is controlled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.