ArticleRegeneration (Oxford, England)2015
Reintegration of the regenerated and the remaining tissues during joint regeneration in the newt Cynops pyrrhogaster.
Article in Regeneration (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Tissue composition shapes differential skeletal integration strategies during axolotl limb regeneration.Nature communications · 2026Article
- Introns as Protective Buffers Against Transposable Elements Invasion During Genome Gigantism in a Newt.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- FGF-stimulated tendon cells embrace a chondrogenic fate with BMP7 in newt tissue culture.Development, growth & differentiation · 2024Article
- The salamander limb: a perfect model to understand imperfect integration during skeletal regeneration.Biology open · 2024Review
- Building a Co-ordinated Musculoskeletal System: The Plasticity of the Developing Skeleton in Response to Muscle Contractions.Advances in anatomy, embryology, and cell biology · 2023Article
- Article
- Salamanders: The molecular basis of tissue regeneration and its relevance to human disease.Current topics in developmental biology · 2021Review
- A comprehensive reference transcriptome resource for the Iberian ribbed newt Pleurodeles waltl, an emerging model for developmental and regeneration biology.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
- Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb.Cell reports · 2018Article
- Changing While Staying the Same: Preservation of Structural Continuity During Limb Evolution by Developmental Integration.Integrative and comparative biology · 2017Article
- Functional joint regeneration is achieved using reintegration mechanism in Xenopus laevis.Regeneration (Oxford, England) · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urodele amphibians, such as newts, can regenerate a functional limb, including joints, after amputation at any level along the proximal-distal axis of the limb. The blastema can regenerate the limb morphology largely independently of the stump after proximal-distal identity has been established, but the remaining and regenerated tissues must be structurally reintegrated (matched in size and shape). Here we used newt joint regeneration as a model to investigate reintegration, because a functionally interlocking joint requires structural integration between its opposing skeletal elements. After forelimbs were amputated at the elbow joint, the joint was regenerated between the remaining and regenerated skeletal elements. The regenerated cartilage was thick around the amputated joint to make a reciprocally interlocking joint structure with the remaining bone. Furthermore, during regeneration, the extracellular matrix of the remaining tissues was lost, suggesting that the remaining tissues might contribute to the morphogenesis of regenerating cartilage. Our results showed that the area of the regenerated cartilage matched the area of the apposed remaining cartilage, thus contributing to formation of a functional structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.