ArticleRegeneration (Oxford, England)2014
Temporal and spatial analysis of enteric nervous system regeneration in the sea cucumber Holothuria glaberrima.
Article in Regeneration (Oxford, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium.bioRxiv : the preprint server for biology · 2024Article
- Neurogenesis during Brittle Star Arm Regeneration Is Characterised by a Conserved Set of Key Developmental Genes.Biology · 2022Article
- A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians.Biology · 2022Review
- Intestine Explants in Organ Culture: A Tool to Broaden the Regenerative Studies in Echinoderms.Journal of marine science and engineering · 2022Article
- Review
- A roadmap for intestinal regeneration.The International journal of developmental biology · 2021Review
- The nervous system component of the mesentery of the sea cucumber Holothuria glaberrima in normal and regenerating animals.Cell and tissue research · 2020Article
- The mesentery as the epicenter for intestinal regeneration.Seminars in cell & developmental biology · 2019Review
- A START-domain-containing protein is a novel marker of nervous system components of the sea cucumber Holothuria glaberrima.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2017Article
- Long Non-Coding RNAs (lncRNAs) of Sea Cucumber: Large-Scale Prediction, Expression Profiling, Non-Coding Network Construction, and lncRNA-microRNA-Gene Interaction Analysis of lncRNAs in Apostichopus japonicus and Holothuria glaberrima During LPS Challenge and Radial Organ Complex Regeneration.Marine biotechnology (New York, N.Y.) · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There is limited information on the regeneration of the enteric nervous system (ENS) following major reconstruction of the digestive tract. We have studied ENS regeneration in the sea cucumber Holothuria glaberrima which undergoes an organogenic process forming a new digestive tract at the tip of the mesentery. Our results show that (1) a degeneration of nerve fibers occurs early in the regeneration process, prior to eventual regeneration; (2) nerve fibers that innervate the regenerating intestine are of extrinsic and intrinsic origin; (3) innervation by extrinsic fibers occurs in a gradient that begins in the proximal area of the regenerate; (4) late events include the appearance of nerve fibers that project from the serosa into the connective tissue and of nerve bundles in the mesothelial layer; (5) neurons and neuroendocrine cells appear early following the formation of the epithelial layers. Our results provide not only a comparative biological approach to study ENS regeneration but also an alternative point of view for the study of enteric neuropathologies and for the innervation of organs made in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.