Evidence map›Paper›PMID 27499815›Full record

ArticleCellular and molecular bioengineering2016

LINCing defective nuclear-cytoskeletal coupling and DYT1 dystonia.

Cosmo A Saunders, G W Gant Luxton

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular bioengineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. DYT-Frontiers in neuroscience · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. TorsinA regulates the LINC to moving nuclei.The Journal of cell biology · 2017
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Cosmo A SaundersDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
G W Gant LuxtonDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
University of Minnesota · US

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Use of specific transcription factors to promote limb regeneration capacityP30AR057220 · NIAMS · UNIVERSITY OF MINNESOTA · PI DARABI, RADBOD · 2009 to 2013
$3.0M
Live-Cell Fluorescence Lifetime FRET Assays for HTSR42DA037622 · NIDA · FLUORESCENCE INNOVATIONS, INC. · PI GILLISPIE, GREGORY DAVID · 2015 to 2016
$1.5M
Using the C. elegans Oocyte to Model the Cell Biology of Early Onset DystoniaR21NS095109 · NINDS · UNIVERSITY OF MINNESOTA · PI GREENSTEIN, DAVID IRWIN · 2015 to 2016
$418k
Live-Cell Fluorescence Lifetime FRET Assays for HTSR41DA037622 · NIDA · FLUORESCENCE INNOVATIONS, INC. · PI GILLISPIE, GREGORY DAVID · 2013 to 2014
$254k
NIAMS NIH HHS P30 AR057220NIAMS NIH HHS T32 AR007612NIDA NIH HHS R41 DA037622NIDA NIH HHS R42 DA037622NINDS NIH HHS R21 NS095109
6 · The paper itself

Abstract

Mechanical forces generated by nuclear-cytoskeletal coupling through the LINC (linker of nucleoskeleton and cytoskeleton) complex, an evolutionarily conserved molecular bridge in the nuclear envelope (NE), are critical for the execution of wholesale nuclear positioning events in migrating and dividing cells, chromosome dynamics during meiosis, and mechanotransduction. LINC complexes consist of outer (KASH (

Identifiers

PMID27499815
PMCPMC4974015
OpenAlexW2298507874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.