ArticleInternational journal of medical sciences2016
Wnt5a Suppresses β-catenin Signaling during Hair Follicle Regeneration.
Article in International journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Single-Cell Profiling Reveals a Protective WNT5A-ATF3-FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Association of TRPV3 gene polymorphisms with wool production traits in Zhexi Angora rabbits.Molecular genetics and genomics : MGG · 2026Article
- Novel Strategies for Androgenetic Alopecia Therapy: Integrating Multifunctional Plant Extracts with Nanotechnology for Advanced Cutaneous Drug Delivery.Pharmaceutics · 2025Review
- Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases.Stem cell reviews and reports · 2025Review
- Review
- Quercetin promotes production of secondary hair follicle stem cells in cashmere goat: a mechanistic study.Frontiers in veterinary science · 2025Article
- Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway.International journal of molecular sciences · 2024Article
- The role of Atg5 gene in tumorigenesis under autophagy deficiency conditions.The Kaohsiung journal of medical sciences · 2024Article
- Molecular monitoring of short- and long-term transcriptional effects of hair growth stimulating agents.PloS one · 2024Article
- Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells.Marine drugs · 2023Article
- The Molecular Mechanism of Natural Products Activating Wnt/β-Catenin Signaling Pathway for Improving Hair Loss.Life (Basel, Switzerland) · 2022Review
- The potential role of hsa_circ_0001079 in androgenetic alopecia via sponging hsa-miR-136-5p.Journal of clinical laboratory analysis · 2022Article
- A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing.BMC genomics · 2021Article
- Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells.Molecules (Basel, Switzerland) · 2020Article
- The role of CTNNB1 and LEF1 in feather follicles development of Anser cygnoides and Anser anser.Genes & genomics · 2020Article
- Review
- Article
- Skin transcriptome reveals the dynamic changes in the Wnt pathway during integument morphogenesis of chick embryos.PloS one · 2018Article
- Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hair follicles display periodic growth. Wnt signaling is a critical regulator for hair follicle regeneration. Previously, we reported that Wnt5a inhibits the telogen-to-anagen transition of hair follicles, but the mechanism by which this process occurs has not yet been reported. Here, we determined the expression patterns of Wnt signaling pathway molecules by quantitative reverse transcription polymerase chain reaction, western blot, and immunohistochemistry and found that β-catenin signaling was suppressed by Wnt5a. We then compared the phenotypes and expression patterns following β-catenin knockdown and Wnt5a overexpression during hair follicle regeneration induced by hair depilation and observed similar patterns. In addition, we performed a rescue experiment in the JB6 cell line and found that the inhibitory effect of Wnt5a on cell proliferation could be rescued by the addition of Wnt3a. Our data reveal that Wnt5a suppresses the activation of β-catenin signaling during hair follicle regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.