ArticleJournal of clinical biochemistry and nutrition2016
Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients.
Article in Journal of clinical biochemistry and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Somatic symptom disorder in gastroesophageal reflux disease: a key factor contributing to severe symptoms and impaired quality of life.Frontiers in medicine · 2026Article
- Laryngopharyngeal reflux disease: debunking false beliefs through evidence-based medicine.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Unveiling the intricacies: Insight into gastroesophageal reflux disease.World journal of gastroenterology · 2025Review
- Article
- A scientometrics analysis and visualization of refractory gastroesophageal reflux disease.Frontiers in pharmacology · 2024Article
- Gastroesophageal reflux in lockdown.Future science OA · 2023Article
- The causal role of gastroesophageal reflux disease in anxiety disorders and depression: A bidirectional Mendelian randomization study.Frontiers in psychiatry · 2023Article
- Article
- Heartburn Center Set-Up in a Community Setting: Engineering and Execution.Frontiers in medicine · 2021Article
- Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub-types of Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-related Disorders.Journal of neurogastroenterology and motility · 2020Article
- Minor psychiatric disorders and objective diagnosis of gastroesophageal reflux disease.Surgical endoscopy · 2019Article
- Cost-utility analysis of a 'vonoprazan-first' strategy versus 'esomeprazole- or rabeprazole-first' strategy in GERD.Journal of gastroenterology · 2019Article
- Depression and Anxiety in Patients with Gastroesophageal Reflux Disorder With and Without Chest Pain.Cureus · 2019Article
- Magnetic sphincter augmentation: Optimal patient selection and referral care pathways.World journal of gastrointestinal endoscopy · 2019Review
- Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study.Journal of neurogastroenterology and motility · 2018Article
- The Proton Pump Inhibitor Nonresponder: a Behavioral Approach to Improvement and Wellness.Current gastroenterology reports · 2018Review
- Proton pump inhibitors and the risk of severe cognitive impairment: The role of posttraumatic stress disorder.Alzheimer's & dementia (New York, N. Y.) · 2017Article
- Gastroesophageal Reflux Disease Associated With Anxiety: Efficacy and Safety of Fixed Dose Combination of Amitriptyline and Pantoprazole.Gastroenterology research · 2017Article
- Prevalence and Correlates of Gastroesophageal Reflux Disease in Southern Iran: Pars Cohort Study.Middle East journal of digestive diseases · 2017Article
- Effects of rikkunshito on quality of life in patients with gastroesophageal reflux disease refractory to proton pump inhibitor therapy.Journal of clinical biochemistry and nutrition · 2017Article
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some patients with gastroesophageal reflux disease experience persistent reflux symptoms despite proton pump inhibitor therapy. These symptoms reduce their health-related quality of life. Our aims were to evaluate the relationship between proton pump inhibitor efficacy and health-related quality of life and to evaluate predictive factors affecting treatment response in Japanese patients. Using the gastroesophageal reflux disease questionnaire, 145 gastroesophageal reflux disease patients undergoing proton pump inhibitor therapy were evaluated and classified as responders or partial-responders. Their health-related quality of life was then evaluated using the 8-item Short Form Health Survey, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale questionnaires. Sixty-nine patients (47.6%) were partial responders. These patients had significantly lower scores than responders in 5/8 subscales and in the mental health component summary of the 8-item Short Form Health Survey. Partial responders had significantly higher Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale scores, including anxiety and depression scores, than those of responders. Non-erosive reflux disease and double proton pump inhibitor doses were predictive factors of partial responders. Persistent reflux symptoms, despite proton pump inhibitor therapy, caused mental health disorders, sleep disorders, and psychological distress in Japanese gastroesophageal reflux disease patients.
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