ArticleJournal of clinical biochemistry and nutrition2016
Effect of vitamin A and Zn supplementation on indices of vitamin A status, haemoglobin level and defecation of children with persistent diarrhea.
Article in Journal of clinical biochemistry and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Zinc supplementation for acute and persistent watery diarrhoea in children: A systematic review and meta-analysis.Journal of global health · 2024Pooled it
- Article
- Serum zinc response to standard therapy in acute versus persistent pediatric diarrhea: a prospective comparative study.Sudanese journal of paediatrics · 2026Article
- Zinc Fortification and Supplementation to Reduce Diarrhea in Children: A Literature Review.Diseases (Basel, Switzerland) · 2025Review
- Enteric pathogens implicated in acute infectious diarrhea among young children in resource-limited region with rapidly growing population: a hospital-based cross-sectional study.Clinical and experimental pediatrics · 2025Article
- Immune Impairment Associated with Vitamin A Deficiency: Insights from Clinical Studies and Animal Model Research.Nutrients · 2022Review
- Article
- Clinicopathological and bacteriological studies on lamb bacterial enteritis and monitoring the oregano oil and vitamins A,DJournal of advanced veterinary and animal research · 2021Article
- Effect of the Source of Zinc on the Tissue Accumulation of Zinc and Jejunal Mucosal Zinc Transporter Expression in Holstein Dairy Calves.Animals : an open access journal from MDPI · 2020Article
- Retinol and α-tocopherol in pregnancy: Establishment of reference intervals and associations with CBC.Maternal & child nutrition · 2020Article
- Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens.Frontiers in cellular and infection microbiology · 2018Review
- Claudin-2 expression is upregulated in the ileum of diarrhea predominant irritable bowel syndrome patients.Journal of clinical biochemistry and nutrition · 2017Article
- Vitamin A deficiency impacts the structural segregation of gut microbiota in children with persistent diarrhea.Journal of clinical biochemistry and nutrition · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the effect of vitamin A and Zn supplementation on vitamin A status, haemoglobin level and defecation of children with persistent diarrhea, a total of 160 paediatric patients were randomly assigned to one of four intervention groups: daily supplementation of 1,500 IU VA for 14 days; daily Zn supplementation for 14 days; daily supplementation with both VA and Zn for 14 days; no supplementation. One hundred twenty-seven children with persistent diarrhea finished intervention (33 were lost to follow-up). Among the 127 children, 41 (32.28%) had anaemia, 104 (81.89%) had a VA deficiency and 38 (29.92%) had an iron insufficiency. Supplementation with VA or VA + Zn enhanced the serum VA levels and ameliorated anaemia. Supplementation with Zn and VA + Zn for 5 days significantly improved defecation, where the VA + Zn treatment resulted in superior outcomes. After 14 days of intervention, the total effectiveness rates were 93.94%, 96.77% and 96.67% in the three groups, significantly greater than that of the non-supplementation group (72.73%). These results indicate that single VA or concurrent VA + Zn supplementation can improve vitamin A status, haemoglobin level and defecation. However, concurrent VA + Zn supplementation is the optimal option and can shorten the duration of persistent diarrhea and markedly improve nutritional status. (www.clinicaltrials.gov registration number: ChiCTR-IOR-14005498).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.