ArticleMayo Clinic proceedings2016
Serum Potassium, Mortality, and Kidney Outcomes in the Atherosclerosis Risk in Communities Study.
Article in Mayo Clinic proceedings, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Potassium levels and the risk of all-cause and cardiovascular mortality among patients with cardiovascular diseases: a meta-analysis of cohort studies.Nutrition journal · 2024Pooled it
- Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology.European heart journal. Cardiovascular pharmacotherapy · 2018Guideline
- Efficacy and Safety of Sodium Zirconium Cyclosilicate for Treatment of Hyperkalemia: An 11-Month Open-Label Extension of HARMONIZE.American journal of nephrology · 2019Trial
- The association between postoperative nadir serum potassium and mortality within 28-day after aortic valve replacement.Journal of cardiothoracic surgery · 2026Article
- Sex differences in potassium regulation: evidence, molecular mechanisms and clinical implications.Biology of sex differences · 2026Review
- Primary Sjögren's Syndrome Presenting With Severe Hypokalemia Due to Distal Renal Tubular Acidosis: A Case Report.Cureus · 2025Article
- Linear association between serum potassium levels and 28-day mortality among ICU patients with diabetes and sepsis: a multicenter study.Frontiers in medicine · 2025Article
- The impact of hyperkalemia on ICU admission and mortality: a retrospective study of Chinese emergency department data.BMC emergency medicine · 2024Observational
- Machine learning models for early prediction of potassium lowering effectiveness and adverse events in patients with hyperkalemia.Scientific reports · 2024Article
- Self-powered freestanding multifunctional microneedle-based extended gate device for personalized health monitoring.Sensors and actuators. B, Chemical · 2024Article
- Article
- Association of Serum Potassium Levels with Mortality and Cardiovascular Events: Findings from the Chinese Multi-provincial Cohort Study.Journal of general internal medicine · 2022Article
- Article
- Association between potassium supplementation and the occurrence of acute kidney injury in patients with hypokalemia administered liposomal amphotericin B: a nationwide observational study.BMC nephrology · 2021Observational
- Reverse pseudohyperkalemia is more than leukocytosis: a retrospective study.Clinical kidney journal · 2021Article
- Fasting serum potassium and long-term mortality in healthy men.BMC public health · 2021Article
- [Cardiac arrest under special circumstances].Notfall & rettungsmedizin · 2021Review
- Potassium Trajectories prior to Dialysis and Mortality following Dialysis Initiation in Patients with Advanced CKD.Nephron · 2021Article
- Initial and Recurrent Hyperkalemia Events in Patients With CKD in Older Adults: A Population-Based Cohort Study.Canadian journal of kidney health and disease · 2021Article
- Normal range of serum potassium, prevalence of dyskalaemia and associated factors in Chinese older adults: a cross-sectional study.BMJ open · 2020Article
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8 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the association between serum potassium, mortality, and kidney outcomes in the general population and whether potassium-altering medications modify these associations. PATIENTS AND
methodsWe studied 15,539 adults in the Atherosclerosis Risk in Communities Study. Cox proportional hazard regression was used to investigate the association of serum potassium at baseline (1987-1989), evaluated categorically (hypokalemia, <3.5 mmol/L; normokalemia, ≥3.5 and <5.5 mmol/L; hyperkalemia, ≥5.5 mmol/L) and continuously using linear spline terms (knots at 3.5 and 5.5 mmol/L), with mortality, sudden cardiac death, incident chronic kidney disease, and end-stage renal disease. The end date of follow-up for all outcomes was December 31, 2012. We also evaluated whether classes of potassium-altering medications modified the association between serum potassium and adverse outcomes.
resultsOverall, 413 (2.7%) of the participants had hypokalemia and 321 (2.1%) had hyperkalemia. In a fully adjusted model, hyperkalemia was significantly associated with mortality (hazard ratio, 1.24; 95% CI, 1.04-1.49) but not sudden cardiac death, chronic kidney disease, or end-stage renal disease. Hypokalemia as a categorical variable was not associated with any outcome; however, associations of hypokalemia with all-cause mortality and kidney outcomes were observed among those who were not taking potassium-wasting diuretics (all P for interaction, <.001).
conclusionsHigher values of serum potassium were associated with a higher risk of mortality in the general population. Lower levels of potassium were associated with adverse kidney outcomes and mortality among participants not taking potassium-wasting diuretics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.