ArticleScientific reports2016
Integrated solid-state nanopore platform for nanopore fabrication via dielectric breakdown, DNA-speed deceleration and noise reduction.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Nanopore Environmental Analysis.JACS Au · 2025Review
- Detection and identification of single ribonucleotide monophosphates using a dual in-plane nanopore sensor made in a thermoplasticLab on a chip · 2024Article
- Large-scale production of polyimide micropore-based flow cells for detecting nano-sized particles in fluids.RSC advances · 2023Article
- Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing.Clinical epigenetics · 2022Review
- Localized Nanopore Fabrication via Controlled Breakdown.Nanomaterials (Basel, Switzerland) · 2022Review
- Low-Area Four-Channel Controlled Dielectric Breakdown System Design for Point-of-Care Applications.Sensors (Basel, Switzerland) · 2022Article
- Enhanced Optical Spectroscopy for Multiplexed DNA and Protein-Sequencing with Plasmonic Nanopores: Challenges and Prospects.Analytical chemistry · 2022Article
- Simple Fabrication of Solid-State Nanopores on a Carbon Film.Micromachines · 2021Article
- Recent advances in integrated solid-state nanopore sensors.Lab on a chip · 2021Review
- Solid-state nanopore fabrication by automated controlled breakdown.Nature protocols · 2020Article
- Solid-state nanopores towards single-molecule DNA sequencing.Journal of human genetics · 2020Review
- Stable fabrication of a large nanopore by controlled dielectric breakdown in a high-pH solution for the detection of various-sized molecules.Scientific reports · 2019Article
- Back-Side Polymer-Coated Solid-State Nanopore Sensors.ACS omega · 2019Article
- Surveying silicon nitride nanopores for glycomics and heparin quality assurance.Nature communications · 2018Article
- Two-step breakdown of a SiN membrane for nanopore fabrication: Formation of thin portion and penetration.Scientific reports · 2018Article
- Fabrication of multiple nanopores in a SiNScientific reports · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The practical use of solid-state nanopores for DNA sequencing requires easy fabrication of the nanopores, reduction of the DNA movement speed and reduction of the ionic current noise. Here, we report an integrated nanopore platform with a nanobead structure that decelerates DNA movement and an insulating polyimide layer that reduces noise. To enable rapid nanopore fabrication, we introduced a controlled dielectric breakdown (CDB) process into our system. DNA translocation experiments revealed that single nanopores were created by the CDB process without sacrificing performance in reducing DNA movement speed by up to 10 μs/base or reducing noise up to 600 pArms at 1 MHz. Our platform provides the essential components for proceeding to the next step in the process of DNA sequencing.
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