ArticleScientific reports2016
A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The Role of Human Viral Entry Receptor Mouse Models in Advancing Antiviral Antibodies and Vaccines.Vaccines · 2026Review
- Animal models for enterovirus 71: Mechanisms, immunity, and applications.Human vaccines & immunotherapeutics · 2025Review
- Severe enterovirus A71 pathogenesis and immune responses in human nucleolin transgenic mice.Medical microbiology and immunology · 2025Article
- Pterostilbene Exhibits Broad-Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV-A71 Challenge.Phytotherapy research : PTR · 2025Article
- Antiviral Activity of Marine BacteriumInternational journal of molecular sciences · 2025Article
- Clinical characteristics of fatal cases of hand, foot and mouth disease in children.Frontiers in pediatrics · 2025Article
- Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71.Virologica Sinica · 2024Article
- TLR4 signalling: the key to controlling EV71 replication and inflammatory response.Frontiers in cellular and infection microbiology · 2024Article
- Experimental animal models for development of human enterovirus vaccine.Clinical and experimental vaccine research · 2023Review
- Murine models of neonatal susceptibility to a clinical strain of enterovirus A71.Virus research · 2023Article
- [Angiotensin-converting enzyme 2 particapates in ozone-induced lung inflammation and airway remodeling in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- A practical method for evaluating theEmerging microbes & infections · 2021Article
- Enterovirus A71 Induces Neurological Diseases and Dynamic Variants in Oral Infection of Human SCARB2-Transgenic Weaned Mice.Journal of virology · 2021Article
- The Disruption of the Endothelial Barrier Contributes to Acute Lung Injury Induced byInternational journal of molecular sciences · 2021Article
- A hSCARB2-transgenic mouse model for Coxsackievirus A16 pathogenesis.Virology journal · 2021Article
- Neonatal Murine Model of Coxsackievirus A2 Infection for the Evaluation of Antiviral Therapeutics and Vaccination.Frontiers in microbiology · 2021Article
- Pathological Features of Enterovirus 71-Associated Brain and Lung Damage in Mice Based on Quantitative Proteomic Analysis.Frontiers in microbiology · 2021Article
- A Polysaccharide Purified FromFrontiers in immunology · 2020Article
- Novel Naturally Occurring Mutations of Enterovirus 71 Associated With Disease Severity.Frontiers in microbiology · 2020Article
- EV71 Infection Induces IFNβ Expression in Neural Cells.Viruses · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterovirus 71 (EV71) is a major threat to children worldwide. Children infected with EV71 could develop subclinical infection and hand-foot-and -mouth disease (HFMD). In severe cases, patients could develop encephalitis, paralysis, pulmonary edema, and death. A more user-friendly and robust animal model is essential to investigating EV71 pathogenesis. Here, we established a hybrid (hSCARB2(+/+)/stat-1(-/-)) mouse strain from crossbreeding SCARB2 transgenic and stat-1 KO mice, and compared the susceptibilities to EV71 infection and pathogenesis between parental and hybrid mice. Virus-encoded VP1 protein can be detected in the streaking nerve fibers in brain and spinal cord. This hybrid mouse strain at 2-week-old age can still be infected with different genotypes of EV71 at 1000-fold lower titer via an ip route. Infected hybrid mice developed earlier onset of CNS disease, paralysis, and death at a higher incidence. These advantages of this novel model meet the urgent need from the scientific community in basic and preclinical research in therapeutics and pathogenesis.
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