ArticleNutritional neuroscience2018
Metabolomic analysis of CSF indicates brain metabolic impairment precedes hematological indices of anemia in the iron-deficient infant monkey.
Article in Nutritional neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial.JAMA pediatrics · 2020Trial
- Novel Erythroid Indices Have Better Prognostic Accuracy than Conventional Erythroid Indices for Early Diagnosis of Iron Deficiency and Associated Brain Metabolomic Changes in Nonhuman Primate Infants.The Journal of nutrition · 2026Article
- Serum Metabolomic Signatures of Iron Deficiency Anemia: An Untargeted LC-HRMS-Based Case-Control Study.Anemia · 2026Article
- Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency.Nutrients · 2024Review
- Prognostic Performance of Hematological and Serum Iron and Metabolite Indices for Detection of Early Iron Deficiency Induced Metabolic Brain Dysfunction in Infant Rhesus Monkeys.The Journal of nutrition · 2024Article
- Bayesian predictive modeling of multi-source multi-way data.Computational statistics & data analysis · 2023Article
- Reticulocyte Hemoglobin Equivalent has Comparable Predictive Accuracy as Conventional Serum Iron Indices for Predicting Iron Deficiency and Anemia in a Nonhuman Primate model of Infantile Iron Deficiency.The Journal of nutrition · 2023Article
- Inhibition of VDAC1 Rescues AMediators of inflammation · 2023Article
- Multiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Choline Supplementation Partially Restores Dendrite Structural Complexity in Developing Iron-Deficient Mouse Hippocampal Neurons.The Journal of nutrition · 2022Article
- Gut Microbial and Metabolic Profiling Reveal the Lingering Effects of Infantile Iron Deficiency Unless Treated with Iron.Molecular nutrition & food research · 2021Article
- Infantile Iron Deficiency Affects Brain Development in Monkeys Even After Treatment of Anemia.Frontiers in human neuroscience · 2021Article
- Early-Life Iron Deficiency and Its Natural Resolution Are Associated with Altered Serum Metabolomic Profiles in Infant Rhesus Monkeys.The Journal of nutrition · 2020Article
- Maternal Prenatal Psychosocial Stress and Prepregnancy BMI Associations with Fetal Iron Status.Current developments in nutrition · 2020Article
- The Effects of Early-Life Iron Deficiency on Brain Energy Metabolism.Neuroscience insights · 2020Review
- Early-Life Iron Deficiency Alters Glucose Transporter-1 Expression in the Adult Rodent Hippocampus.The Journal of nutrition · 2019Article
- The Benefits and Risks of Iron Supplementation in Pregnancy and Childhood.Annual review of nutrition · 2019Article
- Impairment of the Developing Human Brain in Iron Deficiency: Correlations to Findings in Experimental Animals and Prospects for Early Intervention Therapy.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Metabolic phenotyping of malnutrition during the first 1000 days of life.European journal of nutrition · 2019Review
- Phosphocreatine Levels in the Left Thalamus Decline during Wakefulness and Increase after a Nap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesIron deficiency (ID) anemia leads to long-term neurodevelopmental deficits by altering iron-dependent brain metabolism. The objective of the study was to determine if ID induces metabolomic abnormalities in the cerebrospinal fluid (CSF) in the pre-anemic stage and to ascertain the aspects of abnormal brain metabolism affected.
methodsStandard hematological parameters [hemoglobin (Hgb), mean corpuscular volume (MCV), transferrin (Tf) saturation, and zinc protoporphyrin/heme (ZnPP/H)] were compared at 2, 4, 6, 8, and 12 months in iron-sufficient (IS; n = 7) and iron-deficient (ID; n = 7) infant rhesus monkeys. Five CSF metabolite ratios were determined at 4, 8, and 12 months using
resultsID infants developed ID (Tf saturation < 25%) by 4 months of age and all became anemic (Hgb < 110 g/L and MCV < 60 fL) at 6 months. Their heme indices normalized by 12 months. Pyruvate/glutamine and phosphocreatine/creatine (PCr/Cr) ratios in CSF were lower in the ID infants by 4 months (P < 0.05). The PCr/Cr ratio remained lower at 8 months (P = 0.02). ZnPP/H, an established blood marker of pre-anemic ID, was positively correlated with the CSF citrate/glutamine ratio (marginal correlation, 0.34; P < 0.001; family wise error rate = 0.001). DISCUSSION: Metabolomic analysis of the CSF is sensitive for detecting the effects of pre-anemic ID on brain energy metabolism. Persistence of a lower PCr/Cr ratio at 8 months, even as hematological measures demonstrated recovery from anemia, indicate that the restoration of brain energy metabolism is delayed. Metabolomic platforms offer a useful tool for early detection of the impact of ID on brain metabolism in infants.
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