Evidence map›Paper›PMID 27499084›Full record

ArticleNeuron2016

Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury.

Yunju Jin, Sarah E Dougherty, Kevin Wood, Landy Sun, Robert H Cudmore, Aya Abdalla, Geetha Kannan, Mikhail Pletnikov, Parastoo Hashemi, David J Linden

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 91 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Serotonergic Regulation in Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Circuit formation in the adult brain.The European journal of neuroscience · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yunju JinSolomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Sarah E DoughertySolomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Kevin WoodDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
Landy SunSolomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Robert H CudmoreSolomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Aya AbdallaDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
Geetha KannanSolomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA; Department of Psychiatry and Department of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Mikhail PletnikovSolomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA; Department of Psychiatry and Department of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Parastoo HashemiDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
David J LindenSolomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA. Electronic address: dlinden@jhmi.edu.
Johns Hopkins University · USWayne State University · US

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessR01MH083728 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PLETNIKOV, MIKHAIL V · 2009 to 2020
$4.9M
An In Vivo Voltammetric Serotonin Biomarker for Antidepressant EfficacyR01MH106563 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HASHEMI, PARASTOO · 2016 to 2020
$1.6M
Time lapse imaging of serotonin axon regeneration in the neocortex of adult mouseR21NS081467 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LINDEN, DAVID J. · 2012 to 2013
$437k
Mechanisms of Serotonin Axon Regeneration Revealed by In Vivo 2-photon Microscopy in the MouseF32NS090822 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DOUGHERTY, SARAH · 2015 to 2017
$173k
NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH083728NIMH NIH HHS R01 MH106563NINDS NIH HHS F32 NS090822NINDS NIH HHS P30 NS050274NINDS NIH HHS R21 NS081467
6 · The paper itself

Abstract

It is widely believed that damaged axons in the adult mammalian brain have little capacity to regrow, thereby impeding functional recovery after injury. Studies using fixed tissue have suggested that serotonin neurons might be a notable exception, but remain inconclusive. We have employed in vivo two-photon microscopy to produce time-lapse images of serotonin axons in the neocortex of the adult mouse. Serotonin axons undergo massive retrograde degeneration following amphetamine treatment and subsequent slow recovery of axonal density, which is dominated by new growth with little contribution from local sprouting. A stab injury that transects serotonin axons running in the neocortex is followed by local regression of cut serotonin axons and followed by regrowth from cut ends into and across the stab rift zone. Regrowing serotonin axons do not follow the pathways left by degenerated axons. The regrown axons release serotonin and their regrowth is correlated with recovery in behavioral tests.

Indexed as

AnimalsAxonsBrain InjuriesMiceMice, TransgenicNeocortexNerve Regenerationp-ChloroamphetamineReflex, StartleRetrograde DegenerationSerotonergic NeuronsTime-Lapse Imagingp-Chloroamphetamine

Identifiers

PMID27499084
PMCPMC4990493
OpenAlexW2489736910

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.