ArticleNature communications2016
ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Genome-Wide CRISPR Screens Identify ABCG2-Mediated Drug Resistance to the Threonine Tyrosine Kinase (TTK) Inhibitor CFI-402257 in Breast Cancer.International journal of molecular sciences · 2026Article
- Optimization of fermentation conditions and extracellular metabolic profiling of Streptomyces rochei strain W71.BMC microbiology · 2025Article
- Genomic mining of Vibrio parahaemolyticus highlights prevalence of antimicrobial resistance genes and new genetic markers associated with AHPND and tdh + /trh + genotypes.BMC genomics · 2024Article
- Production of selenium nanoparticles occurs through an interconnected pathway of sulphur metabolism and oxidative stress response in Pseudomonas putida KT2440.Microbial biotechnology · 2023Article
- Biosensor for Multimodal Characterization of an Essential ABC Transporter for Next-Generation Antibiotic Research.ACS applied materials & interfaces · 2023Article
- Role of PatAB Transporter in Efflux of Levofloxacin inAntibiotics (Basel, Switzerland) · 2022Article
- Drug-dependent inhibition of nucleotide hydrolysis in the heterodimeric ABC multidrug transporter PatAB from Streptococcus pneumoniae.The FEBS journal · 2022Article
- Distribution, Phylogeny and Evolution of Clinical and EnvironmentalEvolutionary bioinformatics online · 2022Article
- Energetics of lipid transport by the ABC transporter MsbA is lipid dependent.Communications biology · 2021Article
- Impact of spent engine oil contamination on the antibiotic resistome of a tropical agricultural soil.Ecotoxicology (London, England) · 2021Article
- Cloning and Functional Characterization of PutativeJournal of microbiology and biotechnology · 2020Article
- Size-Dependent Inhibitory Effects of Antibiotic Nanocarriers on Filamentation ofNanoscale advances · 2020Article
- A Putative Efflux Transporter of the ABC Family, YbhFSR, inFrontiers in microbiology · 2020Article
- Powering the ABC multidrug exporter LmrA: How nucleotides embrace the ion-motive force.Science advances · 2018Article
- Multidrug efflux pumps: structure, function and regulation.Nature reviews. Microbiology · 2018Review
- Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters.Protein science : a publication of the Protein Society · 2018Review
- Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective.Frontiers in microbiology · 2018Review
- Solute carrier transporters: potential targets for digestive system neoplasms.Cancer management and research · 2018Review
- CD2068 potentially mediates multidrug efflux in Clostridium difficile.Scientific reports · 2017Article
- Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
ATP-binding cassette transporters mediate the transbilayer movement of a vast number of substrates in or out of cells in organisms ranging from bacteria to humans. Current alternating access models for ABC exporters including the multidrug and Lipid A transporter MsbA from Escherichia coli suggest a role for nucleotide as the fundamental source of free energy. These models involve cycling between conformations with inward- and outward-facing substrate-binding sites in response to engagement and hydrolysis of ATP at the nucleotide-binding domains. Here we report that MsbA also utilizes another major energy currency in the cell by coupling substrate transport to a transmembrane electrochemical proton gradient. The dependence of ATP-dependent transport on proton coupling, and the stimulation of MsbA-ATPase by the chemical proton gradient highlight the functional integration of both forms of metabolic energy. These findings introduce ion coupling as a new parameter in the mechanism of this homodimeric ABC transporter.
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