ArticleNature communications2016
Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 112 citations in OpenAlex.
- Identification and Expression Analysis of the CLE Gene Family in Sesame.International journal of molecular sciences · 2026Article
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- Local peptide signalling induces stomatal closure under drought stress.Nature communications · 2025Article
- An updated history of TDIF-PXY signalling: a study in cell fate and tissue patterning.The New phytologist · 2025Review
- Pan-Angiosperm Analysis of the CLE Signaling Peptide Gene Family Unveils Paths, Patterns, and Predictions of Paralog Diversification.Molecular biology and evolution · 2025Article
- Peptides and Reactive Oxygen Species Regulate Root Development.International journal of molecular sciences · 2025Review
- The rise of CLAVATA: evidence for CLAVATA3 and WOX signaling in the fern gametophyte.The Plant journal : for cell and molecular biology · 2025Article
- A major role of class III HD-ZIPs in promoting sugar beet cyst nematode parasitism in Arabidopsis.PLoS pathogens · 2024Article
- Small Peptides: Orchestrators of Plant Growth and Developmental Processes.International journal of molecular sciences · 2024Review
- Endogenous and environmental signals in regulating vascular development and secondary growth.Frontiers in plant science · 2024Article
- Small leucine rich proteoglycans: Biology, function and their therapeutic potential in the ocular surface.The ocular surface · 2023Review
- Molecular Mechanisms Underlying the Establishment and Maintenance of Vascular Stem Cells in Arabidopsis thaliana.Plant & cell physiology · 2023Review
- Article
- Functional Expression of the Ectodomain of Plant Receptor Kinases in Plant Suspension Culture.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3.eLife · 2022Article
- A host-free transcriptome for haustoriogenesis in Cuscuta campestris: Signature gene expression identifies markers of successive development stages.Physiologia plantarum · 2022Article
- Laying it on thick: a study in secondary growth.Journal of experimental botany · 2022Review
- Cell Fate Decisions Within the Vascular Cambium-Initiating Wood and Bast Formation.Frontiers in plant science · 2022Review
- Article
- Peptide Signaling Pathways Regulate Plant Vascular Development.Frontiers in plant science · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plants, leucine-rich repeat receptor-like kinases (LRR-RKs) perceive ligands, including peptides and small molecules, to regulate various physiological processes. TDIF, a member of the CLE peptide family, specifically interacts with the LRR-RK TDR to inhibit meristem differentiation into tracheary elements, and promotes cell proliferation. Here we report the crystal structure of the extracellular domain of TDR in complex with the TDIF peptide. The extracellular domain of TDR adopts a superhelical structure comprising 22 LRRs, and specifically recognizes TDIF by its inner concave surface. Together with our biochemical and sequence analyses, our structure reveals a conserved TDIF-recognition mechanism of TDR among plant species. Furthermore, a structural comparison of TDR with other plant LRR-RKs suggested the activation mechanism of TDR by TDIF. The structure of this CLE peptide receptor provides insights into the recognition mechanism of the CLE family peptides.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.