ArticleScientific reports2016
Hydrogen prevents corneal endothelial damage in phacoemulsification cataract surgery.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Macular pucker and cataract treated with phacoemulsification and IOL implantation combined with small-gauge pars plana vitrectomy: a comparison of outcomes with and without femtosecond laser assistance.Frontiers in medicine · 2025Article
- Subnuclear Phacoemulsification to Reduce Corneal Injury in Nuclear Cataract Surgery: Evidence From a Randomized Controlled Trial.Journal of ophthalmology · 2025Article
- The Neuropeptide α-Melanocyte-Stimulating Hormone Prevents Persistent Corneal Edema following Injury.The American journal of pathology · 2024Article
- Novel Role of Molecular Hydrogen: The End of Ophthalmic Diseases?Pharmaceuticals (Basel, Switzerland) · 2023Review
- Corneal Edema after Cataract Surgery.Journal of clinical medicine · 2023Review
- Ocular Drug Delivery: a Comprehensive Review.AAPS PharmSciTech · 2023Review
- Development of an anti-oxidative intraocular irrigating solution based on reactive persulfides.Scientific reports · 2022Article
- Prophylactic Instillation of Hydrogen-Rich Water Decreases Corneal Inflammation and Promotes Wound Healing by Activating Antioxidant Activity in a Rat Alkali Burn Model.International journal of molecular sciences · 2022Article
- Risk factors for fluctuations in corneal endothelial cell density (Review).Experimental and therapeutic medicine · 2022Review
- Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway.Investigative ophthalmology & visual science · 2021Article
- Development of Animal Models for Lens and Corneal Diseases Using N-Methyl-N-Nitrosourea.Investigative ophthalmology & visual science · 2020Article
- Epigallocatechin 3-Gallate Has a Neuroprotective Effect in Retinas of Rabbits with Ischemia/Reperfusion through the Activation of Nrf2/HO-1.International journal of molecular sciences · 2020Article
- Optimisation of Storage and Transportation Conditions of Cultured Corneal Endothelial Cells for Cell Replacement Therapy.Scientific reports · 2020Article
- Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model.International journal of ophthalmology · 2020Article
- Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress.PloS one · 2020Article
- Combined treatment of phacoemulsification and single-port limited pars plana vitrectomy in acute angle-closure glaucoma.International journal of ophthalmology · 2019Article
- Effect of Reformation of the Anterior Chamber by Air or by a Balanced Salt Solution (BSS) on Corneal Endothelium after Phacoemulsification: A Comparative Study.Journal of ophthalmology · 2018Article
- Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage.Scientific reports · 2017Article
- Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis.PloS one · 2017Article
- The transfer of hydrogen from inert gas to therapeutic gas.Medical gas researchReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In phacoemulsification, ultrasound induces hydroxyl radical (·OH) formation, damaging corneal endothelium. Whether H2 can prevent such oxidative damage in phacoemulsification was examined by in vitro and in vivo studies. H2 was dissolved in a commercial irrigating solution. The effects of H2 against ·OH generation were first confirmed in vitro by electron-spin resonance (ESR) and hydroxyphenyl fluorescein (HPF). ESR showed a significantly decreased signal magnitude, and fluorescence intensity by oxidized HPF was significantly less in the H2-dissolved solution. The effects of H2 in phacoemulsification were evaluated in rabbits, comparing H2-dissolved and control solutions. Five hours after the procedure, the whole cornea was excised and subjected to image analysis for corneal edema, real-time semiquantitative PCR (qPCR) for heme oxygenase (HO)-1, catalase (CAT), superoxide dismutase 1 (SOD1), and SOD2 mRNA, and immunohistochemistry. Corneal edema was significantly less and the increases in anti-oxidative HO-1, CAT and SOD2 mRNA expressions were significantly suppressed in the H2 group. In addition, corneal endothelial cell expressions of two oxidative stress markers, 4-HNE and 8-OHdG, were significantly lower in the H2 group. In conclusion, H2 dissolved in the ocular irrigating solution protected corneal endothelial cells from phacoemulsification-induced oxidative stress and damage.
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Registered trials
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