Evidence map›Paper›PMID 27498551›Full record

ArticleMolecules and cells2016

Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation.

Nayoung Kim, Young-In Yoon, Hyun Ju Yoo, Eunyoung Tak, Chul-Soo Ahn, Gi-Won Song, Sung-Gyu Lee, Shin Hwang

Abstract read
In one paragraph

Article in Molecules and cells, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Evidence for the important role of inflammation in xenotransplantation.Journal of inflammation (London, England) · 2019
    Review
  14. Observational
  15. Article
  16. Immunosuppression Monitoring-What Clinician Needs to Know?Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nayoung KimDepartment of Convergence Medicine & Asan Institute for Life Sciences, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Young-In YoonDivision of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Hyun Ju YooDepartment of Convergence Medicine & Asan Institute for Life Sciences, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Eunyoung TakDepartment of Convergence Medicine & Asan Institute for Life Sciences, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Chul-Soo AhnDivision of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Gi-Won SongDivision of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Sung-Gyu LeeDivision of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Shin HwangDivision of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Discovery of non-invasive diagnostic and predictive biomarkers for acute rejection in liver transplant patients would help to ensure the preservation of liver function in the graft, eventually contributing to improved graft and patient survival. We evaluated selected cytokines and chemokines in the sera from liver transplant patients as potential biomarkers for acute rejection, and found that the combined detection of IL-10, IL-17, and CXCL10 at 1-2 weeks post-operation could predict acute rejection following adult liver transplantation with 97% specificity and 94% sensitivity.

Indexed as

Liver TransplantationAcute DiseaseAdultBiomarkersChemokine CXCL10FemaleGraft RejectionHumansInterleukin-10Interleukin-17MaleMiddle AgedPredictive Value of TestsPrognosisSensitivity and SpecificityBiomarkersChemokine CXCL10CXCL10 protein, humanIL10 protein, humanInterleukin-10Interleukin-17acute rejectionbiomarkerchemokinecytokineliver transplant

Identifiers

PMID27498551
PMCPMC4990757

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.