Evidence map›Paper›PMID 27498277›Full record

ArticleHeart rhythm2016

Validation of electromechanical wave imaging in a canine model during pacing and sinus rhythm.

Julien Grondin, Alexandre Costet, Ethan Bunting, Alok Gambhir, Hasan Garan, Elaine Wan, Elisa E Konofagou

Open access · greenAbstract read
In one paragraph

Article in Heart rhythm, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cardiac Resynchronization Therapy Response Assessment with Electromechanical Activation Mapping within 24 Hours of Device Implantation: A Pilot Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021
    Article
  6. Article
  7. 4D cardiac electromechanical activation imaging.Computers in biology and medicine · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Julien GrondinDepartment of Biomedical Engineering.
Alexandre CostetDepartment of Biomedical Engineering.
Ethan BuntingDepartment of Biomedical Engineering.
Alok GambhirDepartment of Medicine, College of Physicians and Surgeons.
Hasan GaranDepartment of Medicine, College of Physicians and Surgeons.
Elaine WanDepartment of Medicine, College of Physicians and Surgeons.
Elisa E KonofagouDepartment of Biomedical Engineering; Department of Radiology, Columbia University, New York, New York. Electronic address: ek2191@columbia.edu.
Royal College of Physicians · GBColumbia University · US

Funding

EARLY DETECTION AND MAPPING OF ISCHEMIA USING MYOCARDIAL ELASTOGRAPHYR01EB006042 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2006 to 2018
$4.3M
Noninvasive arrhythmia mapping using Electromechanical Wave ImagingR01HL114358 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2012 to 2016
$1.9M
NHLBI NIH HHS R01 HL114358NIBIB NIH HHS R01 EB006042
6 · The paper itself

Abstract

backgroundAccurate determination of regional areas of arrhythmic triggers is of key interest to diagnose arrhythmias and optimize their treatment. Electromechanical wave imaging (EWI) is an ultrasound technique that can image the transient deformation in the myocardium after electrical activation and therefore has the potential to detect and characterize location of triggers of arrhythmias.

objectivesThe objectives of this study were to investigate the relationship between the electromechanical and the electrical activation of the left ventricular (LV) endocardial surface during epicardial and endocardial pacing and during sinus rhythm as well as to map the distribution of electromechanical delays.

methodsIn this study, 6 canines were investigated. Two external electrodes were sutured onto the epicardial surface of the LV. A 64-electrode basket catheter was inserted through the apex of the LV. Ultrasound channel data were acquired at 2000 frames/s during epicardial and endocardial pacing and during sinus rhythm. Electromechanical and electrical activation maps were synchronously obtained from the ultrasound data and the basket catheter, respectively.

resultsThe mean correlation coefficient between electromechanical and electrical activation was 0.81 for epicardial anterior pacing, 0.79 for epicardial lateral pacing, 0.69 for endocardial pacing, and 0.56 for sinus rhythm.

conclusionThe electromechanical activation sequence determined by EWI follows the electrical activation sequence and more specifically in the case of pacing. This finding is of key interest in the role that EWI can play in the detection of the anatomical source of arrhythmias and the planning of pacing therapies such as cardiovascular resynchronization therapy.

Indexed as

Arrhythmias, CardiacHeart Conduction SystemAnimalsCardiac Pacing, ArtificialDisease Models, AnimalDogsEchocardiographyElectric StimulationElectrophysiologic Techniques, CardiacHeart VentriclesImage Processing, Computer-AssistedModels, CardiovascularReproducibility of ResultsArrhythmiasCanine modelElectrical mappingElectromechanical activationNoninvasive imagingPacingUltrasound

Identifiers

PMID27498277
PMCPMC5079821
OpenAlexW2475828613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.