Evidence map›Paper›PMID 27498204›Full record

ReviewProgress in biophysics and molecular biology2016

Toward a theory of organisms: Three founding principles in search of a useful integration.

Ana M Soto, Giuseppe Longo, Paul-Antoine Miquel, Maël Montevil, Matteo Mossio, Nicole Perret, Arnaud Pocheville, Carlos Sonnenschein

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in biophysics and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Towards modelling emergence in plant systems.Quantitative plant biology · 2023
    Article
  5. Article
  6. Article
  7. On biological individuation.Theory in biosciences = Theorie in den Biowissenschaften · 2022
    Article
  8. The essence of life revisited: how theories can shed light on it.Theory in biosciences = Theorie in den Biowissenschaften · 2022
    Article
  9. Biological constraints as norms in evolution.History and philosophy of the life sciences · 2022
    Article
  10. The cancer puzzle: Welcome to organicism.Progress in biophysics and molecular biology · 2021
    Article
  11. Article
  12. From Wingspread to CLARITY: a personal trajectory.Nature reviews. Endocrinology · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. An Integrative Approach Toward Biology, Organisms, and Cancer.Methods in molecular biology (Clifton, N.J.) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ana M SotoCentre Cavaillès, République des Savoirs, CNRS USR3608, Collège de France et Ecole Normale Supérieure, Paris, France; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA. Electronic address: ana.soto@tufts.edu.
Giuseppe LongoCentre Cavaillès, République des Savoirs, CNRS USR3608, Collège de France et Ecole Normale Supérieure, Paris, France; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA.
Paul-Antoine MiquelUniversité de Toulouse 2, 5 Allée Antonio Machado, 31058, Toulouse Cedex 9, France.
Maël MontevilLaboratoire "Matière et Systèmes Complexes" (MSC), UMR 7057 CNRS, Université Paris 7 Diderot, 75205, Paris Cedex 13, France.
Matteo MossioIHPST (CNRS/Paris 1/ENS), 13, Rue du Four, 75006, Paris, France.
Nicole PerretCentre Cavaillès, République des Savoirs, CNRS USR3608, Collège de France et Ecole Normale Supérieure, Paris, France.
Arnaud PochevilleDepartment of Philosophy, Charles Perkins Center, University of Sydney, Sydney, Australia.
Carlos SonnenscheinDepartment of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA; Centre Cavaillès, École Normale Supérieure, Paris, France; Institut d'Etudes Avancees de Nantes, France.

Funding

Mechanisms of developmental toxicity of Bisphenol-AR01ES008314 · NIEHS · TUFTS UNIVERSITY BOSTON · PI SOTO, ANA · 1996 to 2016
$6.8M
NIEHS NIH HHS R01 ES008314
6 · The paper itself

Abstract

Organisms, be they uni- or multi-cellular, are agents capable of creating their own norms; they are continuously harmonizing their ability to create novelty and stability, that is, they combine plasticity with robustness. Here we articulate the three principles for a theory of organisms, namely: the default state of proliferation with variation and motility, the principle of variation and the principle of organization. These principles profoundly change both biological observables and their determination with respect to the theoretical framework of physical theories. This radical change opens up the possibility of anchoring mathematical modeling in biologically proper principles.

Indexed as

Models, BiologicalAnimalsBiological organizationDefault stateIndividuationOrganizational closureVariation

Identifiers

PMID27498204
PMCPMC5097676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.