Evidence map›Paper›PMID 27497985›Full record

ArticleFish physiology and biochemistry2017

Berberine attenuates oxidative stress and hepatocytes apoptosis via protecting mitochondria in blunt snout bream Megalobrama amblycephala fed high-fat diets.

Kang-Le Lu, Li-Na Wang, Ding-Dong Zhang, Wen-Bin Liu, Wei-Na Xu

Abstract read
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Article in Fish physiology and biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 145 citations in OpenAlex.

  1. Berberine alleviates soybean meal-induced enteritis in hybrid yellow catfish (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
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  9. Salinity Tolerance in Freshwater Drum (Animals : an open access journal from MDPI · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kang-Le LuFisheries College, Jimei University, Xiamen, 361021, China.
Li-Na WangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Ding-Dong ZhangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Wen-Bin LiuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. wbliu@njau.edu.cn.
Wei-Na XuSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China. xuweina@sjtu.edu.cn.
Nanjing Agricultural University · CNJimei University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-fat diets may have favorable effects on growth and cost, but high-fat diets often induce excessive fat deposition, resulting in liver damage. This study aimed to identify the hepatoprotective of a Chinese herb (berberine) for blunt snout bream (Megalobrama amblycephala). Fish were fed with a normal diet (LFD, 5 % fat), high-fat diet (HFD, 15 % fat) or berberine-supplemented diets (BSD, 15 % fat with berberine 50 or 100 mg/kg level) for 8 weeks. After the feeding, histology, oxidative status and mitochondrial function of liver were assessed. The results showed that HFD caused fat accumulation, oxidative stress and apoptosis in hepatocytes of fish. Hepatocytes in HFD group appeared to be hypertrophied, with larger liver cells diameter than these of LFD group. Berberine-supplemented diets could attenuate oxidative stress and hepatocytes apoptosis. HFD induced the decreasing mitochondrial complexes activities and bulk density and surface area density. Berberine improved function of mitochondrial respiratory chain via increasing the complex activities. Moreover, the histological results showed that berberine has the potential to repair mitochondrial ultrastructural damage and elevate the density in cells. In conclusion, our study demonstrated that berberine has attenuated liver damage induced by the high fat mainly via the protection for mitochondria.

Indexed as

Alanine TransaminaseAnimalsApoptosisAspartate AminotransferasesBerberineCatalaseCatfishesCholesterolDiet, High-FatFish ProteinsGene ExpressionGlutathioneGlutathione PeroxidaseGlutathione ReductaseHepatocytesLipid MetabolismAlanine TransaminaseAspartate AminotransferasesBerberineCatalaseCholesterolFish ProteinsGlutathioneGlutathione PeroxidaseGlutathione ReductaseMalondialdehydeSuperoxide DismutaseTriglyceridesApoptosisBerberineBlunt snout breamHigh-fat dietMitochondrial functionOxidative stress

Identifiers

PMID27497985
OpenAlexW2496389095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.