Evidence map›Paper›PMID 27497840›Full record

Trial reportBehaviour research and therapy2016

Patient adherence and treatment outcome with exposure and response prevention for OCD: Which components of adherence matter and who becomes well?

Michael G Wheaton, Hanga Galfalvy, Shari A Steinman, Melanie M Wall, Edna B Foa, H Blair Simpson

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Behaviour research and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
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  4. Trauma-Related Compulsions in Obsessive-Compulsive Disorder: Functional Insights From Factor Analysis.Stress and health : journal of the International Society for the Investigation of Stress · 2026
    Article
  5. Article
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  9. Review
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  11. Article
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  20. Obsessive-compulsive disorder.Nature reviews. Disease primers · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael G WheatonFerkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA; New York State Psychiatric Institute, New York, NY, USA; Columbia Psychiatry, Columbia University, New York, NY, USA.
Hanga GalfalvyNew York State Psychiatric Institute, New York, NY, USA; Columbia Psychiatry, Columbia University, New York, NY, USA.
Shari A SteinmanNew York State Psychiatric Institute, New York, NY, USA; Columbia Psychiatry, Columbia University, New York, NY, USA.
Melanie M WallNew York State Psychiatric Institute, New York, NY, USA; Columbia Psychiatry, Columbia University, New York, NY, USA.
Edna B FoaUniversity of Pennsylvania, Philadelphia, PA, USA.
H Blair SimpsonNew York State Psychiatric Institute, New York, NY, USA; Columbia Psychiatry, Columbia University, New York, NY, USA. Electronic address: Simpson@nyspi.columbia.edu.

Funding

Maximizing Treatment Outcome in OCDR01MH045404 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FOA, EDNA B · 1990 to 2016
$5.3M
Maximizing Treatment Outcome in OCDR01MH045436 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI SIMPSON, HELEN BLAIR · 1990 to 2015
$5.0M
Enhancing Patient-Oriented Research and Training in OCDK24MH091555 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SIMPSON, HELEN BLAIR · 2010 to 2014
$742k
NIMH NIH HHS K24 MH091555NIMH NIH HHS R01 MH045404NIMH NIH HHS R01 MH045436
6 · The paper itself

Abstract

Exposure and response prevention (EX/RP) is an evidence-based treatment for obsessive-compulsive disorder (OCD), yet not all patients achieve wellness with EX/RP. The degree to which patients adhere to EX/RP procedures outside of sessions has been found to predict therapy outcomes, including who achieves post-treatment wellness. We sought to investigate which components of treatment adherence most relate to outcome and to develop adherence benchmarks to identify who does and does not become well to provide clinicians with prognostic tools. Adherence data came from 37 adult patients with DSM-IV OCD who received 17 sessions of EX/RP as part of a randomized controlled trial of augmentation strategies for incomplete response to serotonin reuptake inhibitors (SRIs). Therapists rated between-session patient adherence at each exposure session by quantifying: 1) the quantity of homework exposures attempted; 2) the quality of attempted exposures; and 3) the degree of success with response prevention. Each adherence item significantly correlated with post-treatment OCD severity. Success with response prevention proved particularly strongly linked to therapy outcome. Time course analysis of this item accurately identified, relatively early in treatment, who would achieve post-treatment wellness. These data provide an efficient method for differentiating between those patients who will and will not achieve wellness after EX/RP augmentation of SRIs. Limitations and clinical implications of the current findings are discussed.

Indexed as

Cognitive Behavioral TherapyImplosive TherapyPatient ComplianceTreatment OutcomeAdolescentAdultAgedAntipsychotic AgentsCombined Modality TherapyFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderRisperidoneYoung AdultAntipsychotic AgentsRisperidoneExposure and response preventionObsessive-compulsive disorderPatient adherence

Identifiers

PMID27497840
PMCPMC5031484

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.