ArticleInternational journal of colorectal disease2016
Differences between colon and rectal cancer in complications, short-term survival and recurrences.
Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Prognostic value of primary tumor location in colorectal cancer: an updated meta-analysis.Clinical and experimental medicine · 2023Pooled it
- Recovery of physical and mental health within 4 weeks after colorectal surgery: a prospective cohort study.Surgical endoscopy · 2026Article
- The Impact of Postoperative Complications After Colon Cancer Surgery on Locoregional Recurrence: A Population-Based Dutch Cohort Study.Annals of surgical oncology · 2026Article
- From regression to machine learning: improving prediction of rectal cancer recurrence.Annals of coloproctology · 2026Article
- BMX-001 acts as a selective chemoradioprotector in rectal cancer.Redox biochemistry and chemistry · 2026Article
- Association between age and surgical resection for patients with stage II or III colorectal cancer: national study.BJS open · 2026Article
- Clinical Risk Management and Postoperative Outcomes After Colorectal Resection: A Retrospective Observational Study.Journal of personalized medicine · 2026Article
- Evaluating clinicopathological pattern and management of colorectal cancer for adult patients presenting at Queen Elizabeth Central Hospital: a 10-year retrospective review.BMC gastroenterology · 2026Article
- Nomogram predicting short- and long-term outcomes in colon cancer based on CT body composition.International journal of colorectal disease · 2025Article
- Side-Specific Prognostic Factors in Colon Cancer: A Retrospective Analysis of Right- and Left-Sided Tumors.Cancers · 2025Article
- Significance of Naples prognostic score for postoperative complications after colorectal cancer surgery.Surgery today · 2025Article
- Identification of postoperative complications in sigmoid colon cancer and rectal cancer using the C-reactive protein level.Surgical endoscopy · 2025Article
- The impact of postoperative recurrent postoperative ileus on the prognosis of colorectal cancer: a propensity score matched study.Updates in surgery · 2025Article
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- IMMUNOREACT 9 metachronous rectal cancers have high HLA-ABC expression on healthy epithelium but a lower infiltration of CD3+ T cells than primary lesions.Scientific reports · 2024Article
- Examining variations in body composition among patients with colorectal cancer according to site and disease stage.Scientific reports · 2024Article
- Identification of unique rectal cancer-specific subtypes.British journal of cancer · 2024Article
- Diverging likelihood of colon and rectal cancer in Yogyakarta, Indonesia: A cross sectional study.PloS one · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMany apparent differences exist in aetiology, genetics, anatomy and treatment response between colon cancer (CC) and rectal cancer (RC). This study examines the differences in patient characteristics, prevalence of complications and their effect on short-term survival, long-term survival and the rate of recurrence between RC and CC.
methodsFor all stage II-III CC and RC patients who underwent resection with curative intent (2006-2008) in five hospitals in the Netherlands, occurrence of complications, crude survival, relative survival and recurrence rates were compared.
resultsA total of 767 CC and 272 RC patients underwent resection. Significant differences were found for age, gender, emergency surgery, T-stage and grade. CC patients experienced fewer complications compared to RC (p = 0.019), but CC patients had worse short-term mortality rates (1.5 versus 6.7 % for 30-day mortality, p = 0.001 and 5.2 versus 9.5 % for 90-day mortality, p = 0.032). The adjusted HR (overall survival) for CC patients with complications was 1.57 (1.23-2.01; p < 0.001) as compared to patients without complications; for RC, the HR was 1.79 (1.12-2.87; p = 0.015). Relative survival analyses showed high excess mortality in the first months after surgery and a sustained, prolonged negative effect on both CC and RC. Complications were associated with a higher recurrence rate for both CC and RC; adjusted analyses showed a trend towards a significant association.
conclusionLarge differences exist in patient characteristics and clinical outcomes between CC and RC. CC patients have a significantly higher short-term mortality compared to RC patients due to a more severe effect of complications.
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