ReviewNeuroscience and biobehavioral reviews2016
The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development.
Review in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed, 4 syntheses or guidelines pooled it, 303 citations in OpenAlex.
- The Effect of Pubertal Status on Self-Regulation of Behavior and Executive Functions-A Systematic Review.Developmental psychobiology · 2025Pooled it
- Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples.Hormones and behavior · 2020Pooled it
- The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies.Frontiers in psychology · 2020Pooled it
- Age at Menarche and Time Spent in Education: A Mendelian Randomization Study.Behavior genetics · 2017Pooled it
- Puberty suppression and sexual well-being in transgender and gender-diverse individuals: evidence- and experience-based counselling and future research directions.Nature reviews. Urology · 2026Review
- Adolescent Hormonal Contraceptive Use in the Context of Brain Development and Depression Risk: A Review and Considerations for Future Research.Biological psychiatry global open science · 2026Review
- An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.Nature cell biology · 2026Article
- Dynamic alterations and potential roles of gut microbiota and metabolites in Angiostrongylus cantonensis-infected mice and rats.Infectious diseases of poverty · 2026Article
- A Bayesian Modeling Approach to Optimize Longitudinal Biomarker Sampling Schedules Using Hormonal Data.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Associations of Exposure to Common Plasticizers and Organophosphate Pesticides during Pregnancy and in Childhood with Cognitive Performance in Adolescents: A Population-Based Study.Environmental science & technology · 2026Article
- Effects of sex, pubertal stage, and pubertal hormones on frontal and limbic responses to fearful and happy faces during early adolescence.Psychoneuroendocrinology · 2026Article
- Deconstructing Kinsey's Scale: Digit Ratio Correlates Negatively with Gynephilia and Positively with Androphilia in Both Sexes.Human nature (Hawthorne, N.Y.) · 2026Article
- Links between hormonal and pubertal development, and adolescent females' risk for affective symptoms.Psychoneuroendocrinology · 2026Article
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Differential role of anterior and posterior pituitary lobes in healthy aging and perceived stress.Scientific reports · 2025Article
- Hormonal contraceptives in adolescence impact the neuroimmune environment of the medial prefrontal cortex and hippocampus in female rats.Brain, behavior, and immunity · 2025Article
- Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.Nature communications · 2025Article
- Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescence.NeuroImage · 2025Article
- Membrane progesterone and oestrogen receptors modulate GABAergic transmission in the prefrontal cortex of prepubertal male, but not female, mice.Experimental physiology · 2025Article
- Hormonal contraceptives during adolescence impact the female brain and behavior in a rat model.Hormones and behavior · 2025Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Adolescence is a developmental period characterized by dramatic changes in cognition, risk-taking and social behavior. Although gonadal steroid hormones are well-known mediators of these behaviors in adulthood, the role gonadal steroid hormones play in shaping the adolescent brain and behavioral development has only come to light in recent years. Here we discuss the sex-specific impact of gonadal steroid hormones on the developing adolescent brain. Indeed, the effects of gonadal steroid hormones during adolescence on brain structure and behavioral outcomes differs markedly between the sexes. Research findings suggest that adolescence, like the perinatal period, is a sensitive period for the sex-specific effects of gonadal steroid hormones on brain and behavioral development. Furthermore, evidence from studies on male sexual behavior suggests that adolescence is part of a protracted postnatal sensitive period that begins perinatally and ends following adolescence. As such, the perinatal and peripubertal periods of brain and behavioral organization likely do not represent two discrete sensitive periods, but instead are the consequence of normative developmental timing of gonadal hormone secretions in males and females.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.