Evidence map›Paper›PMID 27497692›Full record

ArticleDNA repair2016

Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells.

Keiji Hashimoto, Radha Bonala, Francis Johnson, Arthur P Grollman, Masaaki Moriya

Open access · greenAbstract read
In one paragraph

Article in DNA repair, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Mechanisms of DNA repair and mutagenesis induced by acetaldehyde, acrolein, aristolochic acids, and vinyl chloride.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Keiji HashimotoDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, United States. Electronic address: keiji.hashimoto@stonybrook.edu.
Radha BonalaDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, United States.
Francis JohnsonDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, United States; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, United States.
Arthur P GrollmanDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, United States; Department of Medicine, Stony Brook University, Stony Brook, NY 11794, United States.
Masaaki MoriyaDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, United States.
Stony Brook University · US

Funding

Mechanism of Mammalian Translesion DNA synthesisR01ES018833 · NIEHS · STATE UNIVERSITY NEW YORK STONY BROOK · PI MORIYA, MASAAKI · 2010 to 2014
$1.4M
NIEHS NIH HHS R01 ES018833
6 · The paper itself

Abstract

Translesion DNA synthesis (TLS) operates when replicative polymerases are blocked by DNA lesions. To investigate the mechanism of mammalian TLS, we employed a plasmid bearing a single 7-(deoxyadenosine-N

Indexed as

AnimalsAristolochic AcidsBase SequenceCarcinogensDNA AdductsDNA-Directed DNA PolymeraseDNA Polymerase iotaFibroblastsGene Knockout TechniquesHumansMiceNucleotidyltransferasesPlasmidsY-Family DNA Polymerasesaristolactam Iaristolochic acid IAristolochic AcidsCarcinogensDNA AdductsDNA-Directed DNA PolymeraseDNA Polymerase iotaNucleotidyltransferasesPOLK protein, humanRad30 proteinRev1 protein, mouseY-Family DNA PolymerasesAristolochic acidMutational hotspotPolζRev1Translesion DNA synthesisY-family polymerases

Identifiers

PMID27497692
PMCPMC5048550
OpenAlexW2492130920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.