Evidence map›Paper›PMID 27497299›Full record

ArticleThe EMBO journal2016

NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation.

Sara Haag, Katherine E Sloan, Namit Ranjan, Ahmed S Warda, Jens Kretschmer, Charlotte Blessing, Benedikt Hübner, Jan Seikowski, Sven Dennerlein, Peter Rehling and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 1 synthesis or guideline pooled it, 300 citations in OpenAlex.

  1. Pooled it
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  11. RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026
    Review
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115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Sara HaagInstitute for Molecular Biology, University Medical Center Göttingen Georg-August-University, Göttingen, Germany.
Katherine E SloanInstitute for Molecular Biology, University Medical Center Göttingen Georg-August-University, Göttingen, Germany.
Namit RanjanDepartment of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Ahmed S WardaInstitute for Molecular Biology, University Medical Center Göttingen Georg-August-University, Göttingen, Germany.
Jens KretschmerInstitute for Molecular Biology, University Medical Center Göttingen Georg-August-University, Göttingen, Germany.
Charlotte BlessingInstitute for Molecular Biology, University Medical Center Göttingen Georg-August-University, Göttingen, Germany.
Benedikt HübnerInstitute for Molecular Biology, University Medical Center Göttingen Georg-August-University, Göttingen, Germany.
Jan SeikowskiInstitute for Organic and Biomolecular Chemistry, Georg-August-University, Göttingen, Germany Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Sven DennerleinInstitute for Cellular Biochemistry, University Medical Center Göttingen Georg-August-University, Göttingen, Germany.
Peter RehlingMax Planck Institute for Biophysical Chemistry, Göttingen, Germany Institute for Cellular Biochemistry, University Medical Center Göttingen Georg-August-University, Göttingen, Germany Göttingen Centre for Molecular Biosciences, Georg-August-University, Göttingen, Germany.
Marina V RodninaDepartment of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Claudia HöbartnerInstitute for Organic and Biomolecular Chemistry, Georg-August-University, Göttingen, Germany Markus.Bohnsack@med.uni-goettingen.de claudia.hoebartner@chemie.uni-goettingen.de.ORCID 0000-0001-7063-5456
Markus T BohnsackInstitute for Molecular Biology, University Medical Center Göttingen Georg-August-University, Göttingen, Germany Göttingen Centre for Molecular Biosciences, Georg-August-University, Göttingen, Germany Markus.Bohnsack@med.uni-goettingen.de claudia.hoebartner@chemie.uni-goettingen.de.
Universitätsmedizin Göttingen · DEMax Planck Institute for Biophysical Chemistry · DEUniversity of Göttingen · DE

Funding

European Research Council 339580
6 · The paper itself

Abstract

Mitochondrial gene expression uses a non-universal genetic code in mammals. Besides reading the conventional AUG codon, mitochondrial (mt-)tRNA

Indexed as

Protein BiosynthesisAnimalsCarboxylic Ester HydrolasesCodonHumansMammalsMembrane ProteinsMethyltransferasesMitochondriaRNA, Transfer, MetSequence Analysis, DNAABHD1 protein, humanCarboxylic Ester HydrolasesCodonMembrane ProteinsMethyltransferasesNSUN3 protein, humanRNA, Transfer, MetABH1mitochondriaNSUN3RNA modificationtranslation

Identifiers

PMID27497299
PMCPMC5048346
OpenAlexW2491926383

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.