Evidence map›Paper›PMID 27497153›Full record

ArticlePsychoneuroendocrinology2016

Corticotropin-releasing hormone receptor 1 (CRH-R1) polymorphisms are associated with irritable bowel syndrome and acoustic startle response.

Alexa Orand, Bruce Naliboff, Malin Gadd, Wendy Shih, Tiffany Ju, Angela P Presson, Emeran A Mayer, Lin Chang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Alexa OrandOppenheimer Center for the Neurobiology of Stress and Resilience, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.
Bruce NaliboffOppenheimer Center for the Neurobiology of Stress and Resilience, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.
Malin GaddDivision of Family Medicine, Department of Neurobiology, Healthcare and Society, Karolinska Institute, Stockholm, Sweden.
Wendy ShihDepartment of Biostatistics, David Geffen School of Medicine, University of California, Los Angeles, United States.
Tiffany JuOppenheimer Center for the Neurobiology of Stress and Resilience, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.
Angela P PressonDepartment of Biostatistics, David Geffen School of Medicine, University of California, Los Angeles, United States; Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States.
Emeran A MayerOppenheimer Center for the Neurobiology of Stress and Resilience, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.
Lin ChangOppenheimer Center for the Neurobiology of Stress and Resilience, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, United States. Electronic address: linchang@mednet.ucla.edu.
University of California, Los Angeles · USKarolinska Institutet · SE

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Women's Health and Functional Visceral Disorders CenterP50DK064539 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 2002 to 2017
$17.5M
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2M
NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBSR01AR046122 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHANG, LIN · 1999 to 2010
$2.4M
Treatment of Fear and Pain in Irritable Bowel SyndromeR01NR007768 · NINR · BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE · PI NALIBOFF, BRUCE D · 2002 to 2006
$1.5M
NIAMS NIH HHS R01 AR046122NIDDK NIH HHS P30 DK041301NIDDK NIH HHS P50 DK064539NIDDK NIH HHS R01 DK048351NINR NIH HHS R01 NR007768
6 · The paper itself

Abstract

backgroundCorticotropin-releasing hormone receptor 1 (CRH-R1) in the amygdala and the stria terminalis plays an important role in the activation of central stress circuits. Genetic factors may contribute to the hyperresponsiveness of these circuits in irritable bowel syndrome (IBS).

aimsTo determine if CRH-R1 SNPs are associated with: (1) a diagnosis of IBS, (2) gastrointestinal (GI) symptoms, and (3) acoustic startle response (ASR) to threat, which is mediated by the amygdala via CRH.

methodsThree CRH-R1 SNPS (rs110402, rs242924, and rs7209436) were genotyped using salivary DNA from IBS and healthy control subjects (HCs). Eye blink ASR was obtained during safe (no shock), anticipation (abdominal shock may soon occur) and threat (abdominal shock likely) conditions in a subset of subjects. Associations between each SNP with IBS status, clinical traits and ASR were measured.

results235 IBS patients (mean age 37.5 yrs, 74% F) and 264 HCs (mean age 32.1 yrs, 70% F) were studied. Of these, 57 IBS and 41 HCs underwent the ASR protocol. The presence of IBS was associated with the major allele for all three CRH-R1 SNPs (p=0.009-0.025). Within IBS, the major allele for all three SNPs (p=0.017-0.065) was associated with GI symptom anxiety scores. Within subjects with at least one copy of the major allele for the CRH-R1 SNPs, IBS had significantly lower ASR compared to HCs during threat conditions (p=0.001-0.002). Within IBS, CRH-R1 SNPs were associated with a graded increase in ASR to threat (p=0.007-0.008).

conclusionThese findings support that CRH-R1 contributes to the dysregulated stress responsiveness in IBS.

Indexed as

AdultBlinkingCRF Receptor, Type 1FemaleHumansIrritable Bowel SyndromeMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Corticotropin-Releasing HormoneReflex, AcousticReflex, StartleCRF Receptor, Type 1Receptors, Corticotropin-Releasing HormoneAcoustic startle responseCorticotropin releasing hormone receptor 1Genetic polymorphismIrritable bowel syndrome

Identifiers

PMID27497153
PMCPMC5048544
OpenAlexW2481580141

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.