ArticleInternational journal of cardiology2016
Exercise training bradycardia is largely explained by reduced intrinsic heart rate.
Article in International journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of leisure-time physical activity on blood pressure in people with hypertension: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Effectiveness of short-term cycling interventions in older adults: a randomized trial of hypoxic, blood flow restriction, and eccentric cycling.Scientific reports · 2025Trial
- Different exercise training modalities similarly improve heart rate variability in sedentary middle-aged adults: the FIT-AGEING randomized controlled trial.European journal of applied physiology · 2022Trial
- Heart Rate Variability following Combined Aerobic and Resistance Training in Sedentary Hypertensive Women: A Randomised Control Trial.Indian heart journal · 2018Trial
- Guidelines for rigor and reproducibility of heart rate variability within human cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2026Review
- Effects of 8-weeks Surf Skateboard training on physical fitness in young people.Sports medicine and health science · 2025Article
- Electrocardiographic Assessment of National-Level Triathletes: Sinus Bradycardia and Other Electrocardiographic Abnormalities.Sports (Basel, Switzerland) · 2025Article
- Any old iron, man.Experimental physiology · 2025Article
- Orthostatic blood pressure reactions and resting heart rate in relation to lung function - the Swedish CArdioPulmonary bioImage Study (SCAPIS).BMC pulmonary medicine · 2024Article
- Physical exercise is essential for increasing ventricular contractility in hypertensive rats treated with losartan.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Maximal Resistance Training in the Treatment of Anorexia Nervosa - A Case Report Series.International journal of exercise science · 2024Article
- Assessment of Prevalence, Clinical Characteristics, and Risk Factors Associated With "Low Flow State" Using Cardiac Magnetic Resonance.Mayo Clinic proceedings. Innovations, quality & outcomes · 2023Article
- The aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution.Scientific reports · 2023Article
- Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women.Diabetology international · 2022Article
- Four Weeks of Detraining Induced by COVID-19 Reverse Cardiac Improvements from Eight Weeks of Fitness-Dance Training in Older Adults with Mild Cognitive Impairment.International journal of environmental research and public health · 2021Article
- Admitted for an Eating Disorder: Challenges Clinical Psychologists Face in Working with Patients and Their Families on a Consultation-Liaison Service in a Tertiary Pediatric Hospital.Journal of clinical psychology in medical settings · 2021Article
- Article
- Associations between Intrinsic Heart Rate, P Wave and QT Interval Durations and Pulse Wave Analysis in Patients with Hypertension and High Normal Blood Pressure.International journal of environmental research and public health · 2020Article
- Arrhythmias and Adaptations of the Cardiac Conduction System in Former National Football League Players.Journal of the American Heart Association · 2019Article
- Genetics and the heart rate response to exercise.Cellular and molecular life sciences : CMLS · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionResting heart rate (RHR) declines with exercise training. Possible mechanisms include: 1) increased parasympathetic tone, 2) decreased responsiveness to beta-adrenergic stimulation, 3) decreased intrinsic heart rate or 4) combination of these factors.
objectiveTo determine whether an increase in resting parasympathetic tone or decrease in response to beta-adrenergic stimulation contributes to the decrease in RHR with training.
methods51 screened healthy subjects aged 18-32 (n=20, mean age 26, 11 female) or 65-80 (n=31, mean age 69, 16 female) were tested before and after 6months of supervised exercise training. Heart rate response to parasympathetic withdrawal was assessed using atropine and beta-adrenergic responsiveness during parasympathetic withdrawal using isoproterenol.
resultsTraining increased VO2 max by 17% (28.7±7.7 to 33.6±9.20ml/kg/min, P<0.001). RHR decreased from 62.8±6.6 to 57.6±7.2 beats per minute (P<0.0001). The increase in heart rate in response to parasympathetic withdrawal was unchanged after training (+37.3±12.8 pre vs. +36.4±12.2 beats per min post, P=0.41). There was no change in the heart rate response to isoproterenol after parasympathetic blockade with training (+31.9±10.9 pre vs. +31.0±12.0 post beats per min, P=0.56). The findings were similar in all four subgroups.
conclusionsWe did not find evidence that an increase in parasympathetic tone or a decrease in responsiveness to beta-adrenergic activity accounts for the reduction in resting heart rate with exercise training. We suggest that a decline in heart rate with training is most likely due to decrease in the intrinsic heart rate.
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