ArticlePediatric research2016
Influence of sympathetic activity in the control of peripheral microvascular tone in preterm infants.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- A systematic review to investigate whether birth weight affects the autonomic nervous system in adulthood.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Pooled it
- Relevance of Microvascular Flow Assessments in Critically Ill Neonates and Children: A Systematic Review.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020Pooled it
- Hemodynamic Changes in the Transition Period in the Preterm and Term Infant: Basic Concepts.Turkish archives of pediatrics · 2025Article
- Impact of prematurity on lifelong cardiovascular health: structural and functional considerations.NPJ cardiovascular health · 2024Review
- A Novel Perspective on Neuronal Control of Anatomical Patterning, Remodeling, and Maintenance.International journal of molecular sciences · 2023Review
- The Need to Address Sex as a Biological Variable in Neonatal Clinical Studies.The Journal of pediatrics · 2023Article
- The Association Between Very Premature Infant Body Temperatures Over Time and Respiratory Care.Biological research for nursing · 2021Article
- Birth weight and heart rate autonomic recovery following exercise in healthy term-born adults.Scientific reports · 2021Article
- Heart rate recovery after maximal exercise is impaired in healthy young adults born preterm.European journal of applied physiology · 2019Article
- How to assess hemodynamic status in very preterm newborns in the first week of life?Journal of perinatology : official journal of the California Perinatal Association · 2017Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicrovascular dysregulation following preterm birth is associated with increased illness severity and hypotension, particularly in males. Sympathetic nervous vascular regulation is evident in females. We hypothesized that sympathetic dysfunction in male preterm infants may contribute to a failure of peripheral microvascular vasoconstriction.
methodsMicrovascular blood flow of infants 24-43 wk gestational age was assessed at 6, 24, and 72 h of age by laser Doppler. Blood flow Fourier transformed frequency distribution spectra (low frequency/high frequency ratio) were used to assess the influence of sympathetic tone on microvascular regulation. Total sympathetic output was assessed as urinary normetanephrine.
resultsMicrovascular sympathetic activity at 24 h postnatal age decreased in early preterm males, but not females. Peripheral sympathetic activity increased with advancing postnatal age in females, but decreased in males. In early preterm infants, total normetanephrine outputs increase significantly with postnatal age, in both sexes.
conclusionSympathetic activation following preterm birth is sexually dimorphic, with preterm males having reduced sympathetic tone and reduced upregulation of sympathetic tone following birth. There is evidence of a disconnect between central sympathetic activity and local peripheral microcirculatory sympathetic drive. This may relate to autonomic nervous immaturity and highlights the need to understand how preterm birth may affect autonomic function.
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