ReviewExperimental biology and medicine (Maywood, N.J.)2017
The role of adaptive bone formation in the etiology of stress fracture.
Review in Experimental biology and medicine (Maywood, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Geometric and "True" Densitometric Characteristics of Bones in Athletes with Stress Fracture and Menstrual Disturbances: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2019Pooled it
- Interdisciplinary Occupational Health System for Recovery From Musculoskeletal Injuries in US Army Personnel.JAMA network open · 2026Article
- Article
- Integrating polyphenols and exercise in cancer prevention, treatment, and rehabilitation: cellular and molecular mechanisms linking the injury-recovery-musculoskeletal resilience axis.Frontiers in oncology · 2026Review
- Subchondral and Osteochondral Unit Bone Damage in the Fetlock Region of Sport Horses Using Low-Field MRI: Case Series.Animals : an open access journal from MDPI · 2025Article
- Musculoskeletal Health, Quality, and Injury Profiles in Collegiate Track and Field and Cross-Country Athletes.Journal of musculoskeletal & neuronal interactions · 2025Article
- Multiple Organ Phenotype of Fatigue.Biomolecules · 2025Review
- Comparing incomplete atypical femur fractures in patients with or without bisphosphonate treatment: radiography and bone morphology in a retrospective study of 19 cases.Acta orthopaedica · 2025Article
- Differences in Body Composition, Bone Density, and Tibial Microarchitecture in Division I Female Athletes Participating in Different Impact Loading Sports.Calcified tissue international · 2025Article
- Principles of musculoskeletal sport injuries for epidemiologists: a review.Injury epidemiology · 2024Review
- Cortical and Trabecular Bone Modeling and Implications for Bone Functional Adaptation in the Mammalian Tibia.Bioengineering (Basel, Switzerland) · 2024Review
- Effect of acute resistance exercise on bone turnover in young adults before and after concurrent resistance and interval training.Physiological reports · 2024Article
- Distal Tibial Bone Properties and Bone Stress Injury Risk in Young Men Undergoing Arduous Physical Training.Calcified tissue international · 2023Article
- Impact loading in female runners with single and multiple bone stress injuries during fresh and exerted conditions.Journal of sport and health science · 2023Article
- Changes in Distal Tibial Microarchitecture During Eight Weeks of U.S. Army Basic Combat Training Differ by Sex and Race.JBMR plus · 2023Article
- Utility of HR-pQCT in detecting training-induced changes in healthy adult bone morphology and microstructure.Frontiers in physiology · 2023Review
- Exercise history predicts focal differences in bone volume fraction, mineral density and microdamage in the proximal sesamoid bones of Thoroughbred racehorses.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Unraveling the physiologic paradoxes that underlie exercise prescription for stress fracture prevention.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Generalized Uncoupled Bone Remodeling Associated With Delayed Healing of Fatigue Fractures.JBMR plus · 2022Article
- Lisfranc Sprain with Second Metatarsal Base Adaptive Stress Response in High-Level Athletes: Case Series and Novel Perspective on a Distinct Entity of Chronic Low-Energy Lisfranc Injury.Case reports in orthopedics · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress fractures are common injuries with load-bearing activities. Stress fractures have been reported in the scientific literature for over a century; however, the etiology continues to be investigated with important distinctions made between the contributions of the tissue-level processes of bone remodeling and modeling. In response to novel repetitive loading, increased bone remodeling may serve to replace fatigue-damaged bone while at the same time creating temporary porosity. Much attention has been given to the role of remodeling in the etiology of stress fracture; however, the role of bone modeling has received less attention. Modest increases in modeling, via bone formation on the periosteal surface of long bones in response to mechanical loading, greatly increases the fatigue resistance of bone. Thus, enhancing this adaptive bone formation is a promising target for stress fracture prevention, and a focus on adaptive bone formation may reveal novel risk factors for stress fracture.
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Registered trials
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