ReviewAdvanced drug delivery reviews2017
Beyond conventional antibiotics - New directions for combination products to combat biofilm.
Review in Advanced drug delivery reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 74 citations in OpenAlex.
- Deciphering microbial biofilm: mechanism, infection, and advanced approaches for control.Folia microbiologica · 2026Review
- Targeting Bacterial Infections in Periodontal Disease: From Conventional Antibiotics to Next-Generation Therapeutics.Antibiotics (Basel, Switzerland) · 2026Review
- Formulation-Dependent Antibacterial Performance: Design and Biomedical Applications.Gels (Basel, Switzerland) · 2026Review
- Nanomedicine applications for the treatment of Staphylococcus aureus infections.FEMS microbiology reviews · 2026Review
- Advances in antibiofilm strategies for medical implant-associated infections: emerging technologies and translational challenges.Frontiers in microbiology · 2026Review
- Green synthesized zinc oxide nanoparticles with lemongrass essential oil for the development of an effective herbal mouthwash.Scientific reports · 2025Article
- Greener Synthesis of Eco-Friendly Biodegradable Mesoporous Bioactive Glasses with and Without Thermal Treatment and Its Effects on Drug Delivery and In Vitro Bioactivity.International journal of molecular sciences · 2025Article
- Development of a small animal bone-anchored limb replacement model for infection interventions.OTA international : the open access journal of orthopaedic trauma · 2025Review
- Anti-oral streptococci and anti-biofilm properties ofHeliyon · 2024Article
- Self-Entrapment of Antimicrobial Peptides in Silica Particles for Stable and Effective Antimicrobial Peptide Delivery System.International journal of molecular sciences · 2023Article
- Synthesis of a covalent organic framework with hetero-environmental pores and its medicine co-delivery application.Nature communications · 2023Article
- Lipids in Pathophysiology and Development of the Membrane Lipid Therapy: New Bioactive Lipids.Membranes · 2021Review
- Personalized and Defect-Specific Antibiotic-Laden Scaffolds for Periodontal Infection Ablation.ACS applied materials & interfaces · 2021Article
- Phyto-fabricated silver nanoparticles inducing microbial cell death via reactive oxygen species-mediated membrane damage.IET nanobiotechnology · 2021Article
- Sub-Inhibitory Concentrations of Ciprofloxacin Alone and Combinations with Plant-Derived Compounds againstAntibiotics (Basel, Switzerland) · 2021Article
- Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity.Materials (Basel, Switzerland) · 2021Article
- Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking.NPJ biofilms and microbiomes · 2021Article
- Nanotheranostics: A Possible Solution for Drug-ResistantNanomaterials (Basel, Switzerland) · 2021Review
- The Principles, Mechanisms, and Benefits of Unconventional Agents in the Treatment of Biofilm Infection.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Antibiotic eluting sinus stents.Laryngoscope investigative otolaryngology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Medical device related infections are a significant and growing source of morbidity and mortality. Biofilm formation is a common feature of medical device infections that is not effectively prevented or treated by systemic antibiotics. Antimicrobial medical device combination products provide a pathway for local delivery of antimicrobial therapeutics with the ability to achieve high local concentrations while minimizing systemic side effects. In this review, we present considerations for the design of local antimicrobial delivery systems, which can be facilitated by modeling local pharmacokinetics in the context of the target device application. In addition to the need for local delivery, a critical barrier to progress in the field is the need to incorporate agents effective against biofilm. This article aims to review key properties of antimicrobial peptides that make them well suited to meet the demands of the next generation of antimicrobial medical devices, including broad spectrum activity, rapid and biocidal mechanisms of action, and efficacy against biofilm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.