ReviewInternational journal for parasitology. Drugs and drug resistance2016
TRP channels in schistosomes.
Review in International journal for parasitology. Drugs and drug resistance, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Form and Function in the Digenea, with an Emphasis on Host-Parasite and Parasite-Bacteria Interactions.Advances in experimental medicine and biology · 2024Review
- Making sense of sensory behaviors in vector-borne helminths.Trends in parasitology · 2022Review
- Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity.Biochimie · 2022Article
- Antiparasitic Properties of Cardiovascular Agents against Human Intravascular ParasitePharmaceuticals (Basel, Switzerland) · 2021Article
- Schistosoma mansoni sarco/endoplasmic reticulum CaJournal of bioenergetics and biomembranes · 2020Review
- Schistosome TRP channels: An appraisal.International journal for parasitology. Drugs and drug resistance · 2020Review
- The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP.Trends in parasitology · 2020Review
- The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel.The Journal of biological chemistry · 2019Article
- Anti-schistosomal action of the calcium channel agonist FPL-64176.International journal for parasitology. Drugs and drug resistance · 2019Article
- Article
- Pharmacological or genetic targeting of Transient Receptor Potential (TRP) channels can disrupt the planarian escape response.PloS one · 2019Article
- TRP channels as potential targets for antischistosomals.International journal for parasitology. Drugs and drug resistance · 2018Review
- Temperature-dependent behaviors of parasitic helminths.Neuroscience letters · 2018Review
- Atypical pharmacology of schistosome TRPA1-like ion channels.PLoS neglected tropical diseases · 2018Article
- Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers.PLoS neglected tropical diseases · 2018Article
- Anthelmintics: From discovery to resistance II (San Diego, 2016).International journal for parasitology. Drugs and drug resistance · 2016Article
- Mechanism of the Passage ofIranian journal of parasitologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Praziquantel (PZQ) is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this fact, only a few classes of parasitic helminth ion channels have been assessed for their pharmacological properties or for their roles in parasite physiology. One such overlooked group of ion channels is the transient receptor potential (TRP) channel superfamily. TRP channels share a common core structure, but are widely diverse in their activation mechanisms and ion selectivity. They are critical to transducing sensory signals, responding to a wide range of external stimuli. They are also involved in other functions, such as regulating intracellular calcium and organellar ion homeostasis and trafficking. Here, we review current literature on parasitic helminth TRP channels, focusing on those in schistosomes. We discuss the likely roles of these channels in sensory and locomotor activity, including the possible significance of a class of TRP channels (TRPV) that is absent in schistosomes. We also focus on evidence indicating that at least one schistosome TRP channel (SmTRPA) has atypical, TRPV1-like pharmacological sensitivities that could potentially be exploited for future therapeutic targeting.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.