ArticleBasic research in cardiology2016
Critical contribution of KV1 channels to the regulation of coronary blood flow.
Article in Basic research in cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Sustained HIF activation in adult cardiomyocytes show transient beneficial effect in murine HFpEF model.European heart journal open · 2026Article
- HBasic research in cardiology · 2025Article
- Single-cell transcriptomic analysis of the human vascular atlas provides new insights into vasorelaxation redundancy and heterogeneity.Frontiers in cardiovascular medicine · 2025Article
- Functional Adaptations in Coronary Reactivity following Healthy Pregnancy in Swine.Journal of vascular research · 2025Article
- Review
- Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism.Nature communications · 2022Article
- Myorelaxant Effect of theMolecules (Basel, Switzerland) · 2021Article
- Another Piece of the Puzzle: Voltage-Gated KCirculation research · 2021Article
- Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.Circulation research · 2021Article
- Disentangling the Gordian knot of local metabolic control of coronary blood flow.American journal of physiology. Heart and circulatory physiology · 2020Review
- Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits.Journal of molecular and cellular cardiology · 2019Article
- KMicrocirculation (New York, N.Y. : 1994) · 2018Review
- Shaker-related voltage-gated KMicrocirculation (New York, N.Y. : 1994) · 2018Article
- Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential.Microcirculation (New York, N.Y. : 1994) · 2018Review
- Thrombospondin-1, Free Radicals, and the Coronary Microcirculation: The Aging Conundrum.Antioxidants & redox signaling · 2017Review
- Regulation of myocardial oxygen delivery in response to graded reductions in hematocrit: role of KBasic research in cardiology · 2017Article
- Influence of increased heart rate and aortic pressure on resting indices of functional coronary stenosis severity.Basic research in cardiology · 2017Article
- Kv1.3 channels facilitate the connection between metabolism and blood flow in the heart.Microcirculation (New York, N.Y. : 1994) · 2017Review
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Ion channels in smooth muscle control coronary vascular tone, but the identity of the potassium channels involved requires further investigation. The purpose of this study was to evaluate the functional role of KV1 channels on porcine coronary blood flow using the selective antagonist correolide. KV1 channel gene transcripts were found in porcine coronary arteries, with KCNA5 (encoding KV1.5) being most abundant (P < 0.001). Immunohistochemical staining demonstrated KV1.5 protein in the vascular smooth muscle layer of both porcine and human coronary arteries, including microvessels. Whole-cell patch-clamp experiments demonstrated significant correolide-sensitive (1-10 µM) current in coronary smooth muscle. In vivo studies included direct intracoronary infusion of vehicle or correolide into a pressure-clamped left anterior descending artery of healthy swine (n = 5 in each group) with simultaneous measurement of coronary blood flow. Intracoronary correolide (~0.3-3 µM targeted plasma concentration) had no effect on heart rate or systemic pressure, but reduced coronary blood flow in a dose-dependent manner (P < 0.05). Dobutamine (0.3-10 µg/kg/min) elicited coronary metabolic vasodilation and intracoronary correolide (3 µM) significantly reduced coronary blood flow at any given level of myocardial oxygen consumption (P < 0.001). Coronary artery occlusions (15 s) elicited reactive hyperemia and correolide (3 µM) reduced the flow volume repayment by approximately 30 % (P < 0.05). Taken together, these data support a major role for KV1 channels in modulating baseline coronary vascular tone and, perhaps, vasodilation in response to increased metabolism and transient ischemia.
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Registered trials
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