ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2016
Metformin, Diabetes, and Survival among U.S. Veterans with Colorectal Cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Prognostic value of metformin in cancers: An updated meta-analysis based on 80 cohort studies.Medicine · 2022 · on this mapPooled it
- Diabetes mellitus and colorectal carcinoma outcomes: a meta-analysis.International journal of colorectal disease · 2020Pooled it
- Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression.International journal of colorectal disease · 2020 · on this mapPooled it
- The relationship between diabetes and colorectal cancer prognosis: A meta-analysis based on the cohort studies.PloS one · 2017Pooled it
- Article
- Type II diabetes and metformin use does not affect colorectal cancer prognosis.International journal of cancer · 2025Article
- Summary of Veterans Health Administration Cancer Data Sources.Journal of registry management · 2024Article
- The impact of metformin on survival in diabetes patients with operable colorectal cancer: A nationwide retrospective cohort study.The Journal of international medical research · 2023Article
- The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus.Scientific reports · 2022Article
- MicroRNA, Diabetes Mellitus and Colorectal Cancer.Biomedicines · 2020Review
- Impact of diabetes on colorectal cancer stage and mortality risk: a population-based cohort study.Diabetologia · 2020Article
- Randomized Phase II Trial of Exercise, Metformin, or Both on Metabolic Biomarkers in Colorectal and Breast Cancer Survivors.JNCI cancer spectrum · 2020Article
- Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects.Journal of experimental & clinical cancer research : CR · 2019Review
- Impact of diabetes comorbidity on the efficacy and safety of FOLFOX first-line chemotherapy among patients with metastatic colorectal cancer: a pooled analysis of two phase-III studies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
- Diabetes Medication Use in Association with Survival among Patients of Breast, Colorectal, Lung, or Gastric Cancer.Cancer research and treatment · 2019Article
- Type 2 diabetes and colorectal cancer survival: The multiethnic cohort.International journal of cancer · 2018Article
- A Cohort Study of Metformin and Colorectal Cancer Risk among Patients with Diabetes Mellitus.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Dose-Dependent Relationship Between Metformin and Colorectal Cancer Occurrence Among Patients with Type 2 Diabetes-A Nationwide Cohort Study.Translational oncology · 2018Article
- The association between metformin use and colorectal cancer survival among patients with diabetes mellitus: An updated meta-analysis.Chronic diseases and translational medicine · 2017Article
- Metformin, Diabetes, and Survival among U.S. Veterans with Colorectal Cancer-Response.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMetformin has been associated with improved colorectal cancer survival, but investigations are limited by small numbers of patients and confounding by diabetic severity. We examined the association between metformin use and overall survival (OS) in patients with diabetes and colorectal cancer in a large population of U.S. veterans, while adjusting for measures of diabetic severity.
methodsPatients diagnosed with colorectal cancer from January 2001 to December 2008 were identified from the Veterans Affairs Central Cancer Registry. Multivariable models were used to examine the adjusted association of OS with diabetes and use of antidiabetic medications.
resultsThere were 21,352 patients diagnosed with colorectal cancer identified (n = 16,355 nondiabetic patients, n = 2,038 diabetic patients on metformin, n = 2,136 diabetic patients on medications other than metformin, n = 823 diabetic patients not on antidiabetic medication). Diabetic patients had a significantly worse OS than nondiabetic patients, but metformin users had only a 10% increase in death (HR
conclusionsAmong diabetics with colorectal cancer, metformin use is associated with improved survival, despite adjustments for diabetes severity and other risk factors. IMPACT: These data lend further support to the conduct of randomized studies of possible anticancer effects of metformin among patients with colorectal cancer. Cancer Epidemiol Biomarkers Prev; 25(10); 1418-25. ©2016 AACR.
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