ArticleTransplantation2017
Survival Benefit in Older Patients Associated With Earlier Transplant With High KDPI Kidneys.
Article in Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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Who cites it
65 citing papers in PubMed.
- Kidney Transplant Referral, Activation, and Transplantation Rates in a Single-Center Cohort of Older Adults in Nova Scotia.Clinical transplantation · 2026Article
- Eligibility, timing, and organ quality: indications and outcomes of kidney transplantation in older patients.Kidney international · 2026Review
- Equitable Donor Assessment Model of Deceased Donor Kidney Quality.Kidney international reports · 2026Article
- Impact of Comorbidities on the Long-Term Survival Rate of Patients Aged 60 Years and Older Undergoing Deceased Donor Kidney Transplantation Versus Continued Waitlisting.Journal of clinical medicine · 2026Article
- Health Care Utilization in Elderly Deceased Donor Kidney Transplant Recipients: Does Kidney Donor Profile Index Matter?Kidney360 · 2026Article
- Measuring What Matters: Days Alive and Out of Hospital and Health Care Utilization in Kidney Transplantation.Kidney360 · 2026Article
- Quantifying Center-level Aggressiveness in Transplanting Suboptimal, Deceased Donor Kidneys in the United States.Transplantation direct · 2026Article
- "Rethinking High-KDPI Kidneys: A Multidomain Approach to Predicting Success".Clinical transplantation · 2026Article
- Evaluating outcomes of preemptive kidney transplant in patients over 65 using high-KDPI kidneys compared to non-preemptive recipients.International urology and nephrology · 2026Article
- Left Ventricular Ejection Fraction and Previous Cardiac Revascularization: Impact on Patient Survival, Graft Survival, and Complications in Kidney Transplant Recipients.Transplantation direct · 2025Article
- Impact of acute kidney injury in ≥65-year-old kidney donors on short- and long-term allograft outcomes.Frontiers in medicine · 2025Article
- Comparative analysis of outcomes in high KDPI spectrum kidney transplants using unsupervised machine learning algorithm.PloS one · 2025Article
- The Individual Impact of Machine Perfusion on Liver and Kidney on Donor Expansion in Simultaneous Liver and Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Outcomes Using High KDPI Kidneys in Recipients Over 65 y of Age.Transplantation direct · 2024Article
- Advancing Kidney Transplantation: A Machine Learning Approach to Enhance Donor-Recipient Matching.Diagnostics (Basel, Switzerland) · 2024Article
- Expanding Access to High KDPI Kidney Transplant for Recipients Aged 60 y and Older: Cost Utility and Survival.Transplantation direct · 2024Article
- Preoperative Risk Assessment of Early Kidney Graft Loss.Transplantation direct · 2024Article
- Can We Predict Kidney Graft Function and Graft Survival Using Hypothermic Machine Perfusion Parameters From Donors After Circulatory Death?Transplantation direct · 2024Article
- Predicting Kidney Transplantation Outcomes from Donor and Recipient Characteristics at Time Zero: Development of a Mobile Application for Nephrologists.Journal of clinical medicine · 2024Article
- Comprehensive geriatric assessment predicts listing for kidney transplant in patients with end-stage renal disease: a retrospective cohort study.BMC geriatrics · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundGiven high dialysis mortality rates for patients older than 60 years, accepting a kidney with a high Kidney Donor Profile Index (KDPI) score could enable earlier and potentially preemptive transplantation (preKT). However, evidence regarding the risks of high KDPI allografts in older patients is limited. Our objective was to determine the relative benefit for older patients of KDPI greater than 85% transplant either preemptively or not compared with remaining on the waitlist.
methodsUnited Network of Organ Sharing data from 2003 to 2012 for adult deceased donor kidney transplant candidates was analyzed to evaluate patient survival in patients older than 60 years for preKT and non-preKT KDPI greater than 85% transplants compared with candidates remaining on the waitlist including patients who received KDPI 0% to 85% transplants according to multivariate Cox regression models.
resultsIn the first year posttransplant for KDPI greater than 85% of transplants in recipients older than 60 years, preKT had a reduced mortality hazard (hazards ratio [HR], 0.61; 95% confidence interval [95% CI], 0.41-0.90) and non-preKT an increased mortality hazard (HR, 1.15; 95% CI, 1.03-1.27) compared with the waitlist including KDPI 0% to 85% transplant recipients. At 1 to 2 years and after 2 years, both KDPI greater than 85% groups had significant reductions in mortality (1-2 years: preKT HR, 0.38; 95% CI, [0.23-0.60] and non-preKT HR, 0.52; 95% CI, 0.45-0.61; and 2+ years: preKT HR, 0.50; 95% CI, 0.38-0.66 and non-preKT HR, 0.64; 95% CI, 0.58-0.70, respectively).
conclusionsPreKT and non-preKT KDPI greater than 85% transplant was associated with lower mortality hazard after the first year compared with the waitlist including KDPI 0% to 85% transplants in patients older than 60 years. Further consideration should be given to increased utilization of high KDPI grafts in older patients with the goal of avoiding or limiting time on dialysis.
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